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Merck
모든 사진(1)

주요 문서

A3601

Sigma-Aldrich

Anti-ADAM-19, N-Terminal antibody produced in rabbit

~1 mg/mL, affinity isolated antibody, buffered aqueous glycerol solution

동의어(들):

Anti-A Disintegrin And Metalloproteinase-19, Anti-Meltrin-β

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About This Item

MDL number:
UNSPSC 코드:
12352203
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생물학적 소스

rabbit

결합

unconjugated

항체 형태

affinity isolated antibody

항체 생산 유형

primary antibodies

클론

polyclonal

양식

buffered aqueous glycerol solution

종 반응성

human

농도

~1 mg/mL

기술

western blot: 1:1,000

UniProt 수납 번호

배송 상태

wet ice

저장 온도

−20°C

타겟 번역 후 변형

unmodified

유전자 정보

human ... ADAM19(8728)

일반 설명

ADAM19 or Meltrin-beta belongs to the ADAM (a disintegrin and metalloprotease-like domain) family. ADAM19 is found in muscle, bone, muscle, lung, heart, brain, kidney, and several other cells. This protein shares homology with the fertilins (ADAMs 1 and 2). Studies have reported that ADAM19 is involved in myoblast fusion, similar to sperm-egg fusion aided by ADAMs 1 and 2. Furthermore, ADAM19 has been implicated in osteoblast and dendritic cell differentiation, as well as in the intracellular processing of neuregulin.
Rabbit anti-ADAM-19, N-Terminal antibody localizes human ADAM19. By immunoblotting against the reduced protein, the antibody recognizes bands at 60kDa and 50kDa from cell lysates.

면역원

synthetic peptide corresponding to the N-terminal of furin-activated human ADAM-19.

애플리케이션

Rabbit anti-ADAM-19, N-Terminal antibody can be used for western blot assays at a dilution of 1:1,000. It can also be used for chemiluminescent immunoassays at 1:5,000.

물리적 형태

Solution in 0.01 M phosphate buffered saline containing 50% glycerol and 0.05% sodium azide.

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문서 라이브러리 방문

K Shirakabe et al.
The Journal of biological chemistry, 276(12), 9352-9358 (2000-12-26)
Meltrin beta/ADAM19 is a member of ADAMs (a disintegrin and metalloproteases), which are a family of membrane-anchored glycoproteins that play important roles in fertilization, myoblast fusion, neurogenesis, and proteolytic processing of several membrane-anchored proteins. The expression pattern of meltrin beta
J Fritsche et al.
Blood, 96(2), 732-739 (2000-07-11)
The 1alpha,25-dihydroxyvitamin D(3) (1,25- [OH](2)VD(3)) modulates the differentiation of monocytic cell lines and monocytes (MOs) in vitro. Up to now several target genes of 1,25(OH)(2)VD(3) have been described in monocytic cell lines; however, little is known about target genes in
D Inoue et al.
The Journal of biological chemistry, 273(7), 4180-4187 (1998-03-28)
Here we report the cloning and initial biochemical characterization of the mouse metalloprotease/disintegrin/cysteine-rich (MDC) protein meltrin beta and the analysis of the mRNA expression of four MDC genes (meltrin alpha, meltrin beta, mdc9, and mdc15) in bone cells, including osteoclasts
K Kurohara et al.
Biochemical and biophysical research communications, 270(2), 522-527 (2001-02-07)
Meltrin beta (ADAM19) is a member of the metalloprotease-disintegrin family. We report here chromosomal mapping of the mouse and rat meltrin beta genes and cloning and analysis of the mouse upstream regulatory regions. The meltrin beta transcript shows a spatially
P Wei et al.
Biochemical and biophysical research communications, 280(3), 744-755 (2001-02-13)
The adamalysins are involved in proteolysis, adhesion, fusion, and intracellular signaling. Human ADAM19/adamalysin-19 (A disintegrin and metalloproteinase 19) was identified from primary dendritic cell cDNA libraries. It has a signal sequence, a pro-domain with a "cysteine-switch" residue, a metalloproteinase domain

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