A2169

3′-Azido-3′-deoxythymidine

≥98% (HPLC), powder, reverse transcriptase inhibitor

• 동의어(들): AZT, Azidothymidine, ZDV, Zidovudine
• 실험식(Hill 표기법): C₁₀H₁₃N₅O₄
• CAS Number: 30516-87-1
• Molecular Weight: 267.24
• Beilstein: 3595791
• MDL number: MFCD00006536
• UNSPSC 코드: 12352200
• PubChem Substance ID: 24278143
• NACRES: NA.77

속성

• product name: 3′-Azido-3′-deoxythymidine, ≥98% (HPLC)
• 분석: ≥98% (HPLC)
• 형태: powder
• mp: 113-115 °C (lit.)
• solubility: H₂O: 50 mg/mL
• 저장 온도: −20°C
• SMILES string: CC1=CN([C@H]2C[C@H](N=[N+]=[N-])[C@@H](CO)O2)C(=O)NC1=O
• InChI: 1S/C10H13N5O4/c1-5-3-15(10(18)12-9(5)17)8-2-6(13-14-11)7(4-16)19-8/h3,6-8,16H,2,4H2,1H3,(H,12,17,18)/t6-,7+,8+/m0/s1
• InChI key: HBOMLICNUCNMMY-XLPZGREQSA-N
• 유전자 정보: human ... HIVE1(3095) ; mouse ... Slc29a1(63959)

설명

애플리케이션

3′-Azido-3′-deoxythymidine has been used as the reverse transcriptase inhibitor to inhibit the viral genome integration and as an antimicrobial agent to evaluate its anti-Salmonella activity.

생화학적/생리학적 작용

Azidothymidine (AZT), a thymidine analogue, is a reverse transcriptase inhibitor against the HIV-1 virus. Azidothymidine has been shown to decrease CRISPR-mediated homology-directed repair (HDR) efficiency.

Reverse transcriptase inhibitor active against HIV-1 virus.

특징 및 장점

This compound is a featured product for ADME Tox research. Click here to discover more featured ADME Tox products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.

안전성 정보

• 픽토그램: GHS08
• 신호어: Warning
• 유해 및 위험 성명서: H341,H351
• 예방조치 성명서: P201 - P202 - P280 - P308 + P313 - P405 - P501
• Hazard Classifications: Carc. 2 - Muta. 2
• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 1
• Flash Point (°F): Not applicable
• Flash Point (°C): Not applicable
• 개인 보호 장비: Eyeshields, Gloves, type P3 (EN 143) respirator cartridges