A0466
N-Acetyl-Asp-Glu-Val-Asp-7-amido-4-trifluoromethylcoumarin
≥90% (HPLC), powder
동의어(들):
Ac-DEVD-AFC
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크기 선택
1 MG
₩318,710
모든 사진(1)
크기 선택
보기 변경
1 MG
₩318,710
About This Item
실험식(Hill 표기법):
C30H34F3N5O13
CAS Number:
Molecular Weight:
729.61
MDL number:
UNSPSC 코드:
12352209
PubChem Substance ID:
NACRES:
NA.32
추천 제품
Quality Level
분석
≥90% (HPLC)
양식
powder
색상
white
solubility
H2O: 1 mg/mL
저장 온도
−20°C
SMILES string
CC(C)[C@H](NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CC(O)=O)NC(C)=O)C(=O)N[C@@H](CC(O)=O)C(=O)Nc1ccc2c(OC(=O)C=C2C(F)(F)F)c1
InChI
1S/C30H34F3N5O13/c1-12(2)25(38-26(47)17(6-7-21(40)41)36-28(49)18(10-22(42)43)34-13(3)39)29(50)37-19(11-23(44)45)27(48)35-14-4-5-15-16(30(31,32)33)9-24(46)51-20(15)8-14/h4-5,8-9,12,17-19,25H,6-7,10-11H2,1-3H3,(H,34,39)(H,35,48)(H,36,49)(H,37,50)(H,38,47)(H,40,41)(H,42,43)(H,44,45)/t17-,18-,19-,25-/m0/s1
InChI key
GZDRODOYEFEHGG-NUDCOPPTSA-N
유전자 정보
human ... CASP3(836)
Amino Acid Sequence
NAc-Asp-Glu-Val-Asp-AFC
생화학적/생리학적 작용
A fluorogenic substrate for caspase 3, a protease that is rapidly activated when cells are exposed to apoptotic conditions and that cleaves poly(ADP-ribose) polymerase. The 7-amido-4-trifluoromethylcoumarin derivative has better membrane permeability than the 7-amido-4-methylcoumarin derivative (A1086).
A fluorogenic substrate for caspase 3; has better membrane permeability than the 7-amido-4-methylcoumarin derivative (A1086).
포장
Bottomless glass bottle. Contents are inside inserted fused cone.
Storage Class Code
11 - Combustible Solids
WGK
WGK 3
Flash Point (°F)
Not applicable
Flash Point (°C)
Not applicable
개인 보호 장비
Eyeshields, Gloves, type N95 (US)
Konduru S Sastry et al.
Cell death & disease, 8(6), e2844-e2844 (2017-06-02)
Cancer stem cells (CSCs) are increasingly considered to be responsible for tumor initiation, metastasis and drug resistance. The drug resistance mechanisms activated in CSCs have not been thoroughly investigated. Although neuropeptides such as vasoactive intestinal peptide (VIP) can promote tumor
Doreen Baumann et al.
International journal of medical microbiology : IJMM, 308(3), 387-404 (2018-03-20)
Enteropathogenic Escherichia coli (EPEC) subvert host cell signaling pathways by injecting effector proteins via a Type 3 Secretion System (T3SS). The T3SS-dependent EspB protein is a multi-functional effector protein, which contributes to adherence and translocator pore formation and after injection
Sophie Laine et al.
Molecules (Basel, Switzerland), 26(8) (2021-05-01)
Two DO3A-type ligands conjugated to substrates of urokinase (L3) and caspase-3 (L4) via a propyl-amide linker were synthesized and their lanthanide(III) (Ln3+) complexes studied. A model compound without peptide substrate (L2) and an amine derivative ligand mimicking the state after
Mélodie Grandin et al.
EMBO molecular medicine, 8(8), 863-877 (2016-07-06)
In a number of human cancers, NTN1 upregulation inhibits apoptosis induced by its so-called dependence receptors DCC and UNC5H, thus promoting tumor progression. In other cancers however, the selective inhibition of this dependence receptor death pathway relies on the silencing
Kazuki Akazawa et al.
Bioconjugate chemistry, 29(5), 1720-1728 (2018-05-02)
Highly sensitive imaging of enzymatic activities in the deep tissues of living mammals provides useful information about their biological functions and for developing new drugs; however, such imaging is challenging. 19F magnetic resonance imaging (MRI) is suitable for noninvasive visualization
활성 필터
자사의 과학자팀은 생명 과학, 재료 과학, 화학 합성, 크로마토그래피, 분석 및 기타 많은 영역을 포함한 모든 과학 분야에 경험이 있습니다..
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