93482

Phenylmethanesulfonyl fluoride solution

~0.1 M in ethanol (T)

• 동의어(들): Benzylsulfonyl fluoride, PMSF
• CAS Number: 329-98-6
• Beilstein: 2088311
• MDL number: MFCD00007424
• UNSPSC 코드: 12352202
• PubChem Substance ID: 57653563
• NACRES: NA.77

속성

• 생물학적 소스: microbial; synthetic
• Quality Level: 200
• 형태: liquid
• 농도: ~0.1 M in ethanol (T)
• density: 0.797 g/mL at 20 °C
• 저장 온도: 2-8°C
• SMILES string: FS(=O)(=O)Cc1ccccc1
• InChI: 1S/C7H7FO2S/c8-11(9,10)6-7-4-2-1-3-5-7/h1-5H,6H2
• InChI key: YBYRMVIVWMBXKQ-UHFFFAOYSA-N

설명

애플리케이션

Phenylmethanesulfonyl fluoride solution has been used as a component in the cell lysate buffer in breast adenocarcinoma cell line, fibrosarcoma cell line and D5 hindbrain and spinal cord neural progenitors.

생화학적/생리학적 작용

Administration of PMSF produces analgesia unrelated to its anticholinesterase effect, and prolongs the analagesic effect of centrally administered β-endorphin.

Phenylmethanesulfonyl fluoride (PMSF) is a serine protease inhibitor. It binds covalently to active site residue of proteases and prevents proteolytic activity. PMSF is used in cell lysate buffers during protein purification to prevent target protein degradation. PMSF effectively inhibits the naloxone-precipitated withdrawal jumping.

안전성 정보

• 픽토그램: GHS02,GHS07
• 신호어: Danger
• 유해 및 위험 성명서: H225,H315,H319
• 예방조치 성명서: P210 - P233 - P240 - P241 - P303 + P361 + P353 - P305 + P351 + P338
• Hazard Classifications: Eye Irrit. 2 - Flam. Liq. 2 - Skin Irrit. 2
• Storage Class Code: 3 - Flammable liquids
• WGK: WGK 2
• Flash Point (°F): 53.6 °F - closed cup
• Flash Point (°C): 12 °C - closed cup
• 개인 보호 장비: Faceshields, Gloves, Goggles, type ABEK (EN14387) respirator filter