435R-1

MCM3 (EP202) Rabbit Monoclonal Primary Antibody

• UNSPSC 코드: 12352202
• NACRES: NA.41

속성

• 생물학적 소스: rabbit
• 결합: unconjugated
• 항체 형태: culture supernatant
• 항체 생산 유형: primary antibodies
• 클론: EP202, monoclonal
• 설명: (For In Vitro Diagnostic Use in Select Regions (See Chart))
• 양식: buffered aqueous solution
• 종 반응성: human
• 포장: vial of 0.1 mL concentrate (435R-14); vial of 0.5 mL concentrate (435R-15); bottle of 1.0 mL predilute (435R-17); vial of 1.0 mL concentrate (435R-16); bottle of 7.0 mL predilute (435R-18)
• 제조업체/상표: Cell Marque^®
• 기술: immunohistochemistry (formalin-fixed, paraffin-embedded sections): 1:25-1:100
• 동형: IgG
• 제어: tonsil
• 배송 상태: wet ice
• 저장 온도: 2-8°C
• 시각화: nuclear
• 유전자 정보: human ... MCM3(4172)

설명

일반 설명

MCM3, minichromosome maintenance protein 3, belongs to the MCM family of highly conserved group of DNA-binding proteins known to have a role in the initiation and regulation of DNA replication during the cell cycle.^1-7 MCM3 expression is up-regulated in proliferating cells and absent in terminally differentiated cells. Like Ki-67, MCM3 marks proliferating cells. In a study performed by Endl E., et al., Ki-67 and MCM3 double staining was performed on human tonsil showing that MCM3 stains proliferating cells like Ki-67, and in addition marks cells present in the intermediate layer of epithelium (which are typically negative for Ki-67). Both Ki-67 and MCM3 are not detectable in differentiated cells.⁶ However, unlike Ki-67, MCM3 protein down-regulation is delayed. This suggests that Ki-67 may be expressed during a shorter interval of the cell cycle than MCM3. Anti-MCM3 may be a more reliable proliferation marker than anti-Ki-67.¹

품질

IVD

IVD

IVD

RUO

결합

MCM3 Positive Control Slides, Product No. 435S, are available for immunohistochemistry (formalin-fixed, paraffin-embedded sections).

물리적 형태

Solution in Tris Buffer, pH 7.3-7.7, with 1% BSA and <0.1% Sodium Azide.

제조 메모

Download the IFU specific to your product lot and formatNote: This requires a keycode which can be found on your packaging or product label.

기타 정보

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법적 정보

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