42966

12-Hydroxy-octadecanoicacid polymer with α-hydro-ω-hydroxypoly(oxy-1,2-ethanediyl)

• 동의어(들): HS 15, Macrogol (15)-hydroxystearate, Polyethylene glycol (15)-hydroxystearate, Polyoxyethylated 12-hydroxystearic acid, Solutol^® HS 15
• CAS Number: 70142-34-6
• UNSPSC 코드: 12161900
• PubChem Substance ID: 329756293
• NACRES: NA.25

속성

• 설명: non-ionic
• 양식: paste
• 구성: free macrogoly% (27.0 - 39.0 g/100g (%))
• 불순물: acetic acid (≤ 0.5 g/100g (%)); water (≤ 0.5 g/100g (%)); ≤0.05% acetic acid; ≤0.05% water; ≤1 mg/kg ethylene oxide ((ppm)); ≤1 mg/kg ethylene oxide; ≤1 mg/kg nickel ((ppm)); ≤1 mg/kg nickle; ≤10 mg/kg dioxane ((ppm)); ≤10 mg/kg dioxane; ≤10 mg/kg heavy metals; ≤620 mg/kg Diethylene glycol; ≤620 mg/kg diethylene glycol ((ppm)); ≤620 mg/kg ethylene glycol ((ppm)); ≤620 mg/kg ethylene glycol; <10 mg/kg heavy metals ((ppm))
• 무기 잔류물: (≤ 0.3 g/100g (%))
• pH: 5.0-7.0 (1 g/10 mL in H₂O)
• mp: 25 - 30 °C (77 - 86 °F)
• 산성 값: ≤1.0 mg KOH/g
• 수산기 값: 90‑110 mg KOH/g
• 요오드 값: ≤2.0 g I₂/100 g
• 과산화수소 값: ≤3.0 meq/kg
• 비누화 값: 53‑63 mg KOH/g
• solubility: water: 200 g/L at 30 °C (86 °F)
• density: 1.048 g/cm³ at 20 °C (68 °F); 1.03 g/cm³ at 60 °C (140 °F)
• 음이온 미량물: <1 ppm (Ethylene Oxide); <10 ppm (Dioxane)
• 양이온 미량물: Ni: <1 ppm; heavy metals: <10 ppm
• 응용 분야: sample preservation
• SMILES string: C(CCCCC(CCCCCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCO)O)CCCCC(=O)O
• InChI: 1S/C47H94O19/c48-15-17-53-19-21-55-23-25-57-27-29-59-31-33-61-35-37-63-39-41-65-43-45-66-44-42-64-40-38-62-36-34-60-32-30-58-28-26-56-24-22-54-20-18-52-16-11-7-6-9-13-46(49)12-8-4-2-1-3-5-10-14-47(50)51/h46,48-49H,1-45H2,(H,50,51)
• InChI key: CYAMZYIUAHNTBO-UHFFFAOYSA-N

설명

일반 설명

12-Hydroxy-octadecanoicacid polymer with α-hydro-ω-hydroxypoly(oxy-1,2-ethanediyl), a pH-independent non-ionic surfactant, is an effective solubilizer and emulsifying agent. It is soluble in aqueous media and polar organic solvents however it is not soluble in apolar solvents. Its structure has 12-hydroxystearic acid (lipophilic moiety) and polyethylene glycol (hydrophilic moiety).

애플리케이션

• 12-Hydroxy-octadecanoic acid polymer with α-hydro-ω-hydroxypoly(oxy-1,2-ethanediyl) has been used:
• in dissolving dexamethasone (DEX) to intraperitoneally inject the mice to test its grip strength to measure the muscle force
• in roflumilast preparation to treat rabbits and guinea pigs to study the mechanisms and pharmacological sensitivity of ozone-induced hypertussive responses
• to dissolve finerenone for oral application in in vivo-studies

생화학적/생리학적 작용

12-Hydroxy-octadecanoic acid polymer with α-hydro-ω-hydroxypoly(oxy-1,2-ethanediyl) is mainly used as a solubilizer in parenteral and oral formulations. It is preferred for in vitro screening and in vivo efficacy studies of compounds. 12-Hydroxy-octadecanoic acid polymer with α-hydro-ω-hydroxypoly(oxy-1,2-ethanediyl) is also used in ophthalmic, macromolecule, suppository, and protein formulations due to its solubilization characteristics and safety profiles. It can form micelles typically ranging from 10-15 nm. 12-Hydroxy-octadecanoic acid polymer with α-hydro-ω-hydroxypoly(oxy-1,2-ethanediyl) can be used to develop micro-emulsion IV formulations.

기타 정보

12-Hydroxy-octadecanoic acid polymer with α-hydro-ω-hydroxypoly(oxy-1,2-ethanediyl) is a non-ionic detergent obtained by reacting 15 moles of ethylene oxide with 1 mole of 12-hydroxy stearic acid.

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법적 정보

Solutol is a registered trademark of BASF SE

안전성 정보

• 픽토그램: GHS07
• 신호어: Warning
• 유해 및 위험 성명서: H317
• 예방조치 성명서: P280
• Hazard Classifications: Skin Sens. 1
• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 1
• Flash Point (°F): 521.6 °F
• Flash Point (°C): 272 °C