Fundamental and applied toxicology : official journal of the Society of Toxicology, 23(1), 93-100 (1994-07-01)
One important factor which may influence the extent and rate of percutaneous absorption is the dosing vehicle. The purpose of the experiments described was to compare the effect of dosing vehicles of different polarities on the absorption of two herbicides
Enzyme mediated hydrolysis of fluazifop butyl has been measured with rat and human skin post-mitochondrial fractions. Rat skin had a ten times greater capacity to metabolise fluazifop butyl than human skin, but the enzyme affinities were similar. The post-mitochondrial fraction
Human & experimental toxicology, 13(2), 123-129 (1994-02-01)
1. We have described and compared the use of two blood sampling techniques to measure the kinetics of fluazifop-butyl, a selective herbicide. Following intravenous administration of radiolabelled compound, blood samples were collected from female rats either by tail vein puncture
Human & experimental toxicology, 13(1), 51-60 (1994-01-01)
A sound understanding of the mechanisms determining percutaneous absorption is necessary for toxicological risk assessment of chemicals contacting the skin. As part of a programme investigating these mechanisms we have developed a physiologically based mathematical model. The structure of the
The Annals of occupational hygiene, 37(5), 525-540 (1993-10-01)
This paper reviews the development of biological monitoring as a method of assessing absorption of pesticides during occupational exposure. An approach to human volunteer studies to estimate the relationship between exposure to pesticides and excretion of metabolites is described and