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25 MG
₩235,683
About This Item
실험식(Hill 표기법):
C10H10Br2N2O2
CAS Number:
Molecular Weight:
350.01
Beilstein:
4189453
MDL number:
UNSPSC 코드:
12352108
PubChem Substance ID:
NACRES:
NA.32
추천 제품
제품 라인
BioReagent
분석
≥95.0% (CHN)
mp
170-172 °C (lit.)
solubility
DMF: soluble
acetonitrile: soluble
chloroform: soluble
형광
λex 391 nm in methanol
λex 393 nm; λem 477 nm in 0.1 M Tris pH 7.0, gutathione red
적합성
suitable for fluorescence
저장 온도
2-8°C
SMILES string
CC1=C(CBr)N2N(C1=O)C(=O)C(C)=C2CBr
InChI
1S/C10H10Br2N2O2/c1-5-7(3-11)13-8(4-12)6(2)10(16)14(13)9(5)15/h3-4H2,1-2H3
InChI key
OSIYFMVMZXJKSP-UHFFFAOYSA-N
애플리케이션
Dibromobimane, a bifunctional thiol reagent, is used as a cross-linking agent for cysteine mapping and studies on protein structure/conformation and cross-linking processes.
포장
Bottomless glass bottle. Contents are inside inserted fused cone.
기타 정보
Fluorescent thiol-specific labeling reagent[1]
신호어
Warning
유해 및 위험 성명서
Hazard Classifications
Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
표적 기관
Respiratory system
Storage Class Code
11 - Combustible Solids
WGK
WGK 3
Flash Point (°F)
Not applicable
Flash Point (°C)
Not applicable
개인 보호 장비
dust mask type N95 (US), Eyeshields, Gloves
M Adil Khan et al.
Biochemistry, 48(41), 9745-9756 (2009-09-23)
Membrane-intrinsic enzymes are embedded in lipids, yet how such enzymes interrogate lipid substrates remains a largely unexplored fundamental question. The outer membrane phospholipid:lipid A palmitoyltransferase PagP combats host immune defenses during infection and selects a palmitate chain using its beta-barrel
T W Loo et al.
The Journal of biological chemistry, 275(50), 39272-39278 (2000-10-03)
P-glycoprotein (P-gp) can transport a wide variety of cytotoxic compounds that have diverse structures. Therefore, the drug-binding domain of the human multidrug resistance P-gp likely consists of residues from multiple transmembrane (TM) segments. In this study, we completed cysteine-scanning mutagenesis
Francisco J Sánchez-Gómez et al.
Molecular pharmacology, 78(4), 723-733 (2010-07-16)
Glutathione transferase P1-1 (GSTP1-1) plays crucial roles in cancer chemoprevention and chemoresistance and is a key target for anticancer drug development. Oxidative stress or inhibitor-induced GSTP1-1 oligomerization leads to the activation of stress cascades and apoptosis in various tumor cells.
Yung-Feng Lin et al.
The Journal of biological chemistry, 282(23), 16783-16791 (2007-04-19)
The ArsA ATPase is the catalytic subunit of the ArsAB pump encoded by the arsRDABC operon of Escherichia coli plasmid R773. ArsD is a metallochaperone that delivers As(III) to ArsA, increasing its affinity for As(III), thus conferring resistance to environmental
T W Loo et al.
The Journal of biological chemistry, 272(51), 31945-31948 (1998-01-24)
We identified a thiol-reactive compound, dibromobimane (dBBn), that was a potent stimulator (8.2-fold) of the ATPase activity of Cys-less P-glycoprotein. We then used this compound together with cysteine-scanning mutagenesis to identify residues in transmembrane segment (TM) 6 and TM12 that
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