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Galangin

autophagy inducing flavonoid

• 동의어(들): 3,5,7-Trihydroxyflavone, Norizalpinin
• 실험식(Hill 표기법): C₁₅H₁₀O₅
• CAS Number: 548-83-4
• Molecular Weight: 270.24
• Beilstein: 272179
• EC Number: 208-960-4
• MDL number: MFCD00006833
• UNSPSC 코드: 41116107
• PubChem Substance ID: 57648294
• NACRES: NA.79

속성

• 분석: ≥95% (HPLC)
• 양식: powder
• 색상: yellow
• mp: 214-215 °C (lit.)
• SMILES string: Oc1cc(O)c2C(=O)C(O)=C(Oc2c1)c3ccccc3
• InChI: 1S/C15H10O5/c16-9-6-10(17)12-11(7-9)20-15(14(19)13(12)18)8-4-2-1-3-5-8/h1-7,16-17,19H
• InChI key: VCCRNZQBSJXYJD-UHFFFAOYSA-N
• 유전자 정보: human ... ADORA2A(135) , ADORA3(140) , CYP1A2(1544) ; rat ... Adora1(29290) , Adora2a(25369)

설명

일반 설명

Galangin is a flavonoid isolated from members of the Zingiberaceae family, which are mainly used for herbal medicines.[1]

애플리케이션

Galangin has been used:

• as a test drug to test its ameliorative effect in a rodent model of cisplatin-induced nephrotoxicity[1]
• to test its effect on the differentiation of 3T3-L1 preadipocyte cells into adipocytes[2]
• as an internal standard in nuclear magnetic resonance spectroscopy and mass spectroscopy[3]

생화학적/생리학적 작용

Galangin exhibits antioxidant, anti-apoptotic, anti-inflammatory[1] and anti-obesity properties.[4] In addition, it also possesses anti-genotoxic activity against environmental and dietary carcinogens. Galangin inhibits cancer growth by hindering cancer cell proliferation, induction of apoptosis and autophagy and inhibition of metastasis.[5] Galangin also has an ability to inhibit CYP1A1 (Cytochrome P450, family 1, member A1) activity.[6]

안전성 정보

• 픽토그램: GHS07
• 신호어: Warning
• 유해 및 위험 성명서: H302
• 예방조치 성명서: P264 - P270 - P301 + P312 - P501
• Hazard Classifications: Acute Tox. 4 Oral
• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point (°F): Not applicable
• Flash Point (°C): Not applicable
• 개인 보호 장비: dust mask type N95 (US), Eyeshields, Gloves