T6508

Trifluoroacetic acid

ReagentPlus^®, 99%

• 동의어(들): TFA
• Linear Formula: CF₃COOH
• CAS Number: 76-05-1
• Molecular Weight: 114.02
• Beilstein: 742035
• EC Number: 200-929-3
• MDL number: MFCD00004169
• UNSPSC 코드: 12352106
• PubChem Substance ID: 329826846
• NACRES: NA.21

속성

• vapor density: 3.9 (vs air)
• Quality Level: 200
• vapor pressure: 97.5 mmHg ( 20 °C)
• 제품 라인: ReagentPlus^®
• 분석: 99%
• 형태: liquid
• 불순물: ≤0.05% water
• refractive index: n20/D 1.3 (lit.)
• pH: 1 (10 g/L)
• bp: 72.4 °C (lit.)
• mp: −15.4 °C (lit.)
• solubility: ethanol: soluble 0.33 mL/mL
• density: 1.489 g/mL at 20 °C (lit.)
• SMILES string: OC(C(F)(F)F)=O
• InChI: 1S/C2HF3O2/c3-2(4,5)1(6)7/h(H,6,7)
• InChI key: DTQVDTLACAAQTR-UHFFFAOYSA-N

설명

일반 설명

Trifluoroacetic acid (TFA) is an organofluorine compound used as a reagent in organic synthesis for various acid-catalyzed reactions such as ring-opening of epoxides, biomimetic cyclization, Cope rearrangements, and natural product synthesis. TFA′s physicochemical characteristics provide advantages over other acids because of its high volatility, solubility in organic solvents, and acidic strength. When TFA is used as a reagent the product isolation is simple by evaporation due to its very high volatility. Less volatile acids such as sulfuric acid or p-toluenesulfonic acid may require neutralization or an extractive workup.

애플리케이션

Trifluoroacetic acid can be used as a reagent:      

• For the cleavage of nitrogen and oxygen protecting groups such as N-Boc, N-benzyloxymethyl, benzyl ether, p-methoxybenzyl ether, t-butyl ether, t-butyloxymethyl ether, triphenylmethyl ether, and dimethyl acetals.      
• In the Baeyer–Villiger oxidation reactions in combination with sodium percarbonate.,·      
• For the C-H trifluoromethylation of arenes.

TFA can also be used as:      

• A solvent in atom transfer cyclization reactions and polymer processes.      
• A catalyst in the synthesis of ε-caprolactam via Beckmann rearrangement of cyclohexanone oxime in aprotic solvents.

포장

1mL in each ampule.

법적 정보

ReagentPlus is a registered trademark of Merck KGaA, Darmstadt, Germany

안전성 정보

• 픽토그램: GHS05,GHS07
• 신호어: Danger
• 유해 및 위험 성명서: H314,H332,H412
• 예방조치 성명서: P261 - P273 - P280 - P303 + P361 + P353 - P304 + P340 + P310 - P305 + P351 + P338
• Hazard Classifications: Acute Tox. 4 Inhalation - Aquatic Chronic 3 - Eye Dam. 1 - Skin Corr. 1A
• Storage Class Code: 8A - Combustible corrosive hazardous materials
• WGK: WGK 2