PHR1659

Flucytosine

Pharmaceutical Secondary Standard; Certified Reference Material

• 동의어(들): 5-Fluorocytosine, 4-amino-5-fluoro-2(1H)-pyrimidinone, Flucytosine
• 실험식(Hill 표기법): C₄H₄FN₃O
• CAS Number: 2022-85-7
• Molecular Weight: 129.09
• Beilstein: 127285
• EC Number: 217-968-7
• MDL number: MFCD00006035
• UNSPSC 코드: 41116107
• PubChem Substance ID: 329823537
• NACRES: NA.24

속성

• Grade: certified reference material; pharmaceutical secondary standard
• Quality Level: 300
• Agency: traceable to Ph. Eur. F0175000; traceable to USP 1272000
• API family: flucytosine
• CofA: current certificate can be downloaded
• 포장: pkg of 1 g
• 기술: HPLC: suitable; gas chromatography (GC): suitable
• mp: 298-300 °C (dec.) (lit.)
• 응용 분야: pharmaceutical (small molecule)
• 형식: neat
• 저장 온도: 2-30°C
• SMILES string: NC1=NC(=O)NC=C1F
• InChI: 1S/C4H4FN3O/c5-2-1-7-4(9)8-3(2)6/h1H,(H3,6,7,8,9)
• InChI key: XRECTZIEBJDKEO-UHFFFAOYSA-N

설명

일반 설명

Pharmaceutical secondary standards for application in quality control, provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards.
Flucytosine is an antimycotic drug that can be effectively utilized against severe Candida and Cryptococcus infections.[1]

애플리케이션

Flucytosine may be used as a pharmaceutical reference standard for the determination of the analyte in pharmaceutical formulations[1][2][3] by various chromatography techniques.

These Secondary Standards are qualified as Certified Reference Materials. These are suitable for use in several analytical applications including but not limited to pharma release testing, pharma method development for qualitative and quantitative analyses, food and beverage quality control testing, and other calibration requirements.

생화학적/생리학적 작용

Nucleoside analog that has antifungal activities. 5-FC is deaminated by cytosine deaminase to product 5-fluorouracil, resulting in RNA miscoding. 5-Fluorocytosine inhibits DNA and RNA synthesis and interferes with ribosomal protein synthesis.

분석 메모

These secondary standards offer multi-traceability to the USP, EP and BP primary standards, where they are available.

기타 정보

This Certified Reference Material (CRM) is produced and certified in accordance with ISO 17034 and ISO/IEC 17025. All information regarding the use of this CRM can be found on the certificate of analysis.

각주

To see an example of a Certificate of Analysis for this material enter LRAA5760 in the slot below. This is an example certificate only and may not be the lot that you receive.

안전성 정보

• 픽토그램: GHS08
• 신호어: Warning
• 유해 및 위험 성명서: H361
• 예방조치 성명서: P281
• Hazard Classifications: Repr. 2
• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 2
• Flash Point (°F): Not applicable
• Flash Point (°C): Not applicable