P9375

1,10-Phenanthroline monohydrate

reagent grade

• 동의어(들): o-Phenanthroline monohydrate
• 실험식(Hill 표기법): C₁₂H₈N₂ · H₂O
• CAS Number: 5144-89-8
• Molecular Weight: 198.22
• Beilstein: 4008096
• EC Number: 200-629-2
• MDL number: MFCD00149973
• UNSPSC 코드: 12352116
• PubChem Substance ID: 24278663
• NACRES: NA.77

속성

• 생물학적 소스: synthetic (organic)
• Quality Level: 200
• Grade: reagent grade
• 형태: powder
• mp: 100-104 °C (lit.)
• solubility: methanol: 200 mM (Stock solution is stable for months at –20° C.)
• SMILES string: O.c1cnc2c(c1)ccc3cccnc23
• InChI: 1S/C12H8N2.H2O/c1-3-9-5-6-10-4-2-8-14-12(10)11(9)13-7-1;/h1-8H;1H2
• InChI key: PPQJCISYYXZCAE-UHFFFAOYSA-N
• 유전자 정보: human ... FNTA(2339)

설명

일반 설명

Phenanthroline is a heterocyclic organic compound, which forms complexes with metal ions. These complexes have wide applications in biochemistry, catalysis and analytical chemistry. It complexes with iron and is exploited as a redox indicator.

애플리케이션

1,10-Phenanthroline monohydrate has been used:

• as an inhibitor of metalloproteinase (MMP) in MDA-MB-231 breast cancer cells
• as a negative control in in situ zymography of mice heart samples
• in in vitro resveratrol chelation and reducing activities assays to chelate iron

When complexed with copper, it possesses nuclease activity that has been used to study DNA-protein interactions.

생화학적/생리학적 작용

Metalloprotease inhibitor; chelates iron, zinc and other divalent metals. Effective concentration 1-10 mM.

안전성 정보

• 픽토그램: GHS06,GHS09
• 신호어: Danger
• 유해 및 위험 성명서: H301,H410
• 예방조치 성명서: P264 - P273 - P301 + P310 - P391 - P405 - P501
• Hazard Classifications: Acute Tox. 3 Oral - Aquatic Acute 1 - Aquatic Chronic 1
• Storage Class Code: 6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
• WGK: WGK 3
• Flash Point (°F): Not applicable
• Flash Point (°C): Not applicable
• 개인 보호 장비: dust mask type N95 (US), Eyeshields, Faceshields, Gloves, type P2 (EN 143) respirator cartridges