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E3893

Sigma-Aldrich

(−)-Epicatechin gallate

≥98% (HPLC), from green tea

동의어(들):

(−)-cis-2-(3,4-Dihydroxyphenyl)-3,4-dihydro-1(2H)-benzopyran-3,5,7-triol 3-gallate, (−)-cis-3,3′,4′,5,7-Pentahydroxyflavane 3-gallate, 3-O-Galloylepicatechin

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크기 선택

10 MG
₩522,015

₩522,015

예상 입고일2025년 4월 07일세부사항

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모든 사진(2)

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10 MG
₩522,015

About This Item

실험식(Hill 표기법):
C22H18O10
CAS Number:
1257-08-5
Molecular Weight:
442.37
MDL number:
MFCD00075936
UNSPSC 코드:
12352205
PubChem Substance ID:
24894531
NACRES:
NA.21

₩522,015

예상 입고일2025년 4월 07일세부사항

벌크 견적 요청

생물학적 소스

green tea

분석

≥98% (HPLC)

응용 분야

metabolomics
vitamins, nutraceuticals, and natural products

저장 온도

2-8°C

SMILES string

Oc1cc(O)c2C[C@@H](OC(=O)c3cc(O)c(O)c(O)c3)[C@H](Oc2c1)c4ccc(O)c(O)c4

InChI

1S/C22H18O10/c23-11-6-14(25)12-8-19(32-22(30)10-4-16(27)20(29)17(28)5-10)21(31-18(12)7-11)9-1-2-13(24)15(26)3-9/h1-7,19,21,23-29H,8H2/t19-,21-/m1/s1

InChI key

LSHVYAFMTMFKBA-TZIWHRDSSA-N

유전자 정보

human ... CYP1A2(1544)

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관련 카테고리

일반 설명

(−)-Epicatechin gallate is one of the major polyphenols present in green tea.[1] It belongs to the catechin gallates group of organic compounds. ECG has a chemical structure like that of (−)-epigallocatechin gallate (EGCG), the other major polyphenol found in green tea.[2]

애플리케이션

(−)-Epicatechin gallate has been used:
  • in cell proliferation assays on the human brain microvascular endothelial cells (HBMVECs) to understand its effectiveness against anti-ischemic/reperfusion injury[2]
  • as an inhibitor in Human Salivary α-Amylase (HAS) and α-Glucosidase (AGH) in inhibition assays[3]
  • may be used as a cancer chemopreventive polyphenol in two human colorectal cell lines HCT-116 and SW-480[4]
  • as an inhibitor to in vitro collagenase and elastase enzymes[5]
  • as a supplement in spermatozoa incubation to check its effectiveness against oxidative stress[6]

생화학적/생리학적 작용

(−)-Epicatechin gallate (ECG), a potent free-radical scavenger[2] has an inhibitory effect on collagenase and elastase enzymes making it an anti-aging agent.[5] It displays antiproliferative effects on human colorectal cells and hence is a chemo-preventative agent.[4] It influences cell survival, preventing apoptosis or autophagy by promoting cell proliferation in oxygen-glucose deprived human brain microvascular endothelial cells.[2] Being structurally and functionally similar to EGCG, ECG might be involved in balancing the mammalian target of rapamycin (mTOR)-AMP-activated protein kinase (AMPK) pathways in endoplasmic reticulum stress. It prevents cell death in this scenario by showing resistance against oxygen-deprived cells.[7] ECG may contribute in preventing oxidative stress. It effectively inhibits secretory sphingomyelinase in many disease states[8] and provides protection for human spermatozoa in Assisted reproductive technology (ART).[6]

픽토그램

Exclamation mark
GHS07

신호어

Warning

유해 및 위험 성명서

H315,H319,H335

Hazard Classifications

Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

표적 기관

Respiratory system

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point (°F)

Not applicable

Flash Point (°C)

Not applicable

개인 보호 장비

Eyeshields, Gloves, type N95 (US)

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시험 성적서(COA)

Lot/Batch Number
WXBF5281V
WXBD8804V
WXBD9038V
WXBD6835V
WXBD3508V

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문서 라이브러리 방문

Lee Wah Koh et al.
Journal of agricultural and food chemistry, 58(1), 148-154 (2010-01-07)
Current work investigated the ability of different tea (green, oolong and black teas) in inhibiting human salivary alpha-amylase (HSA) and mammalian alpha-glucosidase (AGH). The inhibitory profiles were correlated to their major polyphenol content (theaflavins and catechins). The fully fermented black
Guang-Jian Du et al.
Nutrients, 4(11), 1679-1691 (2012-12-04)
Green tea is a popular drink consumed daily by millions of people around the world. Previous studies have shown that some polyphenol compounds from green tea possess anticancer activities. However, systemic evaluation was limited. In this study, we determined the
Bing Fu et al.
Oxidative medicine and cellular longevity, 2019, 7824684-7824684 (2019-04-10)
Green tea is one of the most beverages with antioxidants and nutrients. As one of the major components of green tea, (-)-epicatechin gallate (ECG) was evaluated for its antioxidative properties in the present study. Cell proliferation assay, tube formation, cell
Keiko Kobayashi et al.
Journal of nutritional science and vitaminology, 62(2), 123-129 (2016-06-07)
Sphingomyelinases (SMases) are key enzymes involved in many diseases which are caused by oxidative stress, such as atherosclerosis, diabetes mellitus, nonalcoholic fatty liver disease, and Alzheimer's disease. SMases hydrolyze sphingomyelin to generate ceramide, a well-known pro-apoptotic lipid. SMases are classified
Marianna Holczer et al.
Oxidative medicine and cellular longevity, 2018, 6721530-6721530 (2018-04-11)
The maintenance of cellular homeostasis is largely dependent on the ability of cells to give an adequate response to various internal and external stimuli. We have recently proposed that the life-and-death decision in endoplasmic reticulum (ER) stress response is defined
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문서

Dietary Antioxidants

Antioxidants protect biological systems from oxidative damage produced by oxygen-containing free radicals and from redoxactive transition metal ions such as iron, copper, and cadmium.

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