52619

Hexamethyldisilazane

for GC derivatization, LiChropur^™, ≥99.0% (GC)

• 동의어(들): HMDS
• Linear Formula: (CH₃)₃SiNHSi(CH₃)₃
• CAS Number: 999-97-3
• Molecular Weight: 161.39
• Beilstein: 635752
• EC Number: 213-668-5
• MDL number: MFCD00008259
• UNSPSC 코드: 12000000
• PubChem Substance ID: 329757861
• NACRES: NA.22

속성

• Grade: derivatization grade ((GC derivatization)); for GC derivatization
• Quality Level: 100
• 분석: ≥99.0% (GC)
• 양식: liquid
• 품질: LiChropur^™
• 반응 적합성: reagent type: derivatization reagent; reaction type: Silylations
• 기술: gas chromatography (GC): suitable
• refractive index: n20/D 1.407 (lit.); n20/D 1.408
• bp: 125 °C (lit.)
• SMILES string: C[Si](C)(C)N[Si](C)(C)C
• InChI: 1S/C6H19NSi2/c1-8(2,3)7-9(4,5)6/h7H,1-6H3
• InChI key: FFUAGWLWBBFQJT-UHFFFAOYSA-N

설명

일반 설명

Hexamethyldisilazane (HMDS) is a commercially available, silylating agent,[1][2] which is used as an alternative for the preparation of silyl ethers from hydroxyl compounds.[2]

애플리케이션

Learn more in the Product Information

Hexamethyldisilazane is suitable for the derivatization of alcohols, U-aminobutyric acid, pesticidal carbamates and urea, 3,4-Dihydroxyphenylglycol, 4-hydroxycoumarins, hydroxyfatty acids, n-hydroxy-2-fluorenylacetamide, kerb cycle acid, malonaldehyde, monoglycerides, phenylpyruvic acid, shikimic acid, unsaturated fatty acid esters (or methyl esters), and related compounds.

It may be used as a derivatizing reagent for the analysis of bioamines and their acidic metabolites,[3] phenol, hydroquinone and catechol[4] in urine samples, mixtures of free fatty acids and metal soaps in paint samples[5] using gas chromatography/mass spectrometry (GC/MS).

Suitable for the derivatization of alcohols, Υ-aminobutyric acid, pesticidal carbamates and urea, 3,4-Dihydroxyphenylglycol, 4-hydroxycoumarins, hydroxyfatty acids, n-hydroxy-2-fluorenylacetamide, kerb cycle acid, malonaldehyde, monoglycerides, phenylpyruvic acid, shikimic acid, unsaturated fatty acid esters (or methyl esters), and related compounds.

특징 및 장점

• HMDS is inexpensive and has a relatively low boiling point (124-127 °C).        
• It can be used without solvent but its silylating power can be increased by various (mostly acidic) catalysts.        
• The only reaction byproduct, ammonia, can leave the reaction mixture as the reaction goes to completion.

기타 정보

Important silylating agent[6][7]

Reagent for 2-hydroxypyrimidine, polytrimethylsilyloxy, trimethylsilyl and trimethylsilyl oximes.

법적 정보

LiChropur is a trademark of Merck KGaA, Darmstadt, Germany

안전성 정보

• 픽토그램: GHS02,GHS06
• 신호어: Danger
• 유해 및 위험 성명서: H225,H302 + H332,H311,H412
• 예방조치 성명서: P210 - P273 - P280 - P301 + P312 - P303 + P361 + P353 - P304 + P340 + P312
• Hazard Classifications: Acute Tox. 3 Dermal - Acute Tox. 4 Inhalation - Acute Tox. 4 Oral - Aquatic Chronic 3 - Flam. Liq. 2
• Storage Class Code: 3 - Flammable liquids
• WGK: WGK 2
• Flash Point (°F): 52.5 °F - closed cup
• Flash Point (°C): 11.4 °C - closed cup
• 개인 보호 장비: Faceshields, Gloves, Goggles, type ABEK (EN14387) respirator filter