33894

Clotrimazole

VETRANAL^®, analytical standard

• 동의어(들): 1-(o-Chloro-α,α-diphenylbenzyl)imidazole, 1-(o-Chlorotrityl)imidazole, 1-[(2-Chlorophenyl)diphenylmethyl]-1H-imidazole
• 실험식(Hill 표기법): C₂₂H₁₇ClN₂
• CAS Number: 23593-75-1
• Molecular Weight: 344.84
• EC Number: 245-764-8
• MDL number: MFCD00057220
• UNSPSC 코드: 41116107
• PubChem Substance ID: 329754531
• NACRES: NA.24

속성

• Grade: analytical standard
• 제품 라인: VETRANAL^®
• 유통기한: limited shelf life, expiry date on the label
• 기술: HPLC: suitable; gas chromatography (GC): suitable
• 항생제 활성 스펙트럼: fungi
• 응용 분야: agriculture; environmental
• 형식: neat
• 동작 모드: protein synthesis | interferes
• SMILES string: Clc1ccccc1C(c2ccccc2)(c3ccccc3)n4ccnc4
• InChI: 1S/C22H17ClN2/c23-21-14-8-7-13-20(21)22(25-16-15-24-17-25,18-9-3-1-4-10-18)19-11-5-2-6-12-19/h1-17H
• InChI key: VNFPBHJOKIVQEB-UHFFFAOYSA-N

설명

일반 설명

Clotrimazole, a non-toxic, systemic, imidazole derivative[1] with broad-spectrum antimycotic activity, is primarily used in the treatment of oropharyngeal candidiasis.[2][3]

Its mode of action involves the inhibition of ergosterol synthesis, which leads to structural and functional damage of the cell membrane.[4]

애플리케이션

Clotrimazole may be used as a reference standard for the determination of the analyte in topical creams[1] and ear drops[5] by reversed-phase high-performance liquid chromatographic (RP-HPLC) method.[5]

Clotrimazole may be used as an analytical reference standard for the determination of the analyte in:

• Milk samples using solid-phase extraction followed by high-performance liquid chromatography (SPE-HPLC).[6]
• Environmental water samples using dispersive liquid-liquid microextraction followed by high-performance liquid chromatography with tandem mass spectrometry (HPLC-MS/MS).[4]

Refer to the product′s Certificate of Analysis for more information on a suitable instrument technique. Contact Technical Service for further support.

법적 정보

VETRANAL is a registered trademark of Merck KGaA, Darmstadt, Germany

안전성 정보

• 픽토그램: GHS07,GHS09
• 신호어: Warning
• 유해 및 위험 성명서: H302,H315,H319,H410
• 예방조치 성명서: P264 - P270 - P273 - P301 + P312 - P302 + P352 - P305 + P351 + P338
• Hazard Classifications: Acute Tox. 4 Oral - Aquatic Acute 1 - Aquatic Chronic 1 - Eye Irrit. 2 - Skin Irrit. 2
• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3
• 개인 보호 장비: dust mask type N95 (US), Eyeshields, Gloves