12805

(Benzotriazol-1-yloxy)tripyrrolidinophosphonium hexafluorophosphate

≥97.0% (TLC), for peptide synthesis

• 동의어(들): PyBOP^®
• Linear Formula: C₁₈H₂₈N₆OP · PF₆
• CAS Number: 128625-52-5
• Molecular Weight: 520.39
• Beilstein: 3584612
• MDL number: MFCD00077411
• UNSPSC 코드: 12352101
• PubChem Substance ID: 329749882
• NACRES: NA.22

속성

• 제품명: (Benzotriazol-1-yloxy)tripyrrolidinophosphonium hexafluorophosphate, purum, ≥97.0% (TLC)
• grade: purum
• Quality Level: 200
• 분석: ≥97.0% (TLC)
• 양식: solid
• 반응 적합성: reaction type: Coupling Reactions
• mp: ~150 °C; 154-156 °C (dec.) (lit.)
• 응용 분야: peptide synthesis
• 저장 온도: 2-8°C
• SMILES string: F[P-](F)(F)(F)(F)F.C1CCN(C1)[P+](On2nnc3ccccc23)(N4CCCC4)N5CCCC5
• InChI: 1S/C18H28N6OP.F6P/c1-2-10-18-17(9-1)19-20-24(18)25-26(21-11-3-4-12-21,22-13-5-6-14-22)23-15-7-8-16-23;1-7(2,3,4,5)6/h1-2,9-10H,3-8,11-16H2;/q+1;-1
• InChI key: VIAFLMPQBHAMLI-UHFFFAOYSA-N

설명

일반 설명

(Benzotriazol-1-yloxy)tripyrrolidinophosphonium hexafluorophosphate (PyBOP) is an activator of carboxyl group commonly used in peptide synthesis. It also participates in the carboxylic acid esterification.[1] It shows characteristics similar to benzotriazol-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate (BOP) and can be utilized as an alternative to BOP in peptide bond formation.[2]

애플리케이션

(Benzotriazol-1-yloxy)tripyrrolidinophosphonium hexafluorophosphate (PyBOP) may be used in the following studies:

• As coupling reagent in the preparation strategies for peptide-oligonucleotide conjugates.[3]
• Synthesis of structured pure triacylglycerol (TAG) regioisomers.[1]
• As coupling reagent in the synthesis of a 3,5-pyrazolidinedione on soluble polyethylene glycol (PEG) polymer support.[4]
• Synthesis of herceptin- nanoparticles.[5]

Analogue of the BOP coupling reagent which does not form carcinogenic HMPA as by-product.

법적 정보

PyBOP is a registered trademark of Merck KGaA, Darmstadt, Germany

안전성 정보

• 픽토그램: GHS07,GHS09
• 신호어: Warning
• 유해 및 위험 성명서: H302,H317,H410
• 예방조치 성명서: P261 - P264 - P273 - P280 - P301 + P312 - P302 + P352
• Hazard Classifications: Acute Tox. 4 Oral - Aquatic Acute 1 - Aquatic Chronic 1 - Skin Sens. 1
• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point (°F): Not applicable
• Flash Point (°C): Not applicable
• 개인 보호 장비: dust mask type N95 (US), Eyeshields, Gloves