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Merck
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주요 문서

SCT037

Sigma-Aldrich

BioTracker Far-red Labile Fe2+ Dye

Live Cell imaging probe for labile ferrous (Fe2+) ions, localizing inside endoplasmic reticulum (ER). Also suitable for flow cytometry.

동의어(들):

ER and golgi Fe2+ probe, cellular iron II ion probe

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5 X 50 NMOL
₩1,053,164

₩1,053,164

예상 입고일2025년 4월 04일세부사항

모든 사진(1)

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보기 변경
5 X 50 NMOL
₩1,053,164

About This Item

UNSPSC 코드:
12352207
NACRES:
NA.47

₩1,053,164

예상 입고일2025년 4월 04일세부사항

양식

lyophilized (solid blue)

응용 분야

cell analysis

검출 방법

fluorometric

관련 카테고리

일반 설명

Iron, the most abundant transition metal in our bodies, is involved in a number of biologically important processes such as respiration, oxygen transport, and energy production in collaboration with oxygen. In living cells, iron exists mainly as ferrous (Fe2+) and ferric (Fe3+) ionic forms. As a major contributor to oxidative damage of cells, Fe2+ is implicated in serious diseases such as cancers and neurodegenerative disorders, because of its ability to produce harmful reactive oxygen species via contact with oxygen, superoxide, and hydrogen peroxide (H2O2).BioTracker far-red labile Fe2+ dye is a fluorescent probe that specifically detects labile iron (II) ions (Fe2+). This probe is designed to selectively react with only Fe2+ separately from other metal ions and irreversibly turns into a far-red fluorescent substance. It mainly localizes inside endoplasmic reticulum (ER) and/or golgi bodies. It can also be used with a flow cytometer equipped with a red laser. FerroFarRed shows almost no cytotoxicity at concentrations up to 100 μM (~20 times that of generally used concentrations).This product is same as FerroFarRedTM (GC903-01) from Goryo Chemical, Inc.Spectral Properties:Absorbance (max): 646nmEmission (max): 662nm (Far-red)Research Category:Live Cell Dye

면책조항

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point (°F)

Not applicable

Flash Point (°C)

Not applicable

시험 성적서(COA)

제품의 로트/배치 번호를 입력하여 시험 성적서(COA)을 검색하십시오. 로트 및 배치 번호는 제품 라벨에 있는 ‘로트’ 또는 ‘배치’라는 용어 뒤에서 찾을 수 있습니다.

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질문

1–3 / 3 질문  

  1. does this reagent stain Fe2+ localized only inside endoplasmic reticulum (ER)?

    1 답변

    1. This item localizes primarily, but not exclusively, inside the endoplasmic reticulum (ER). This compound may also localize in the Golgi. While not confirmed, there is some indication that the material may detect Fe2+ in the cytoplasmic pool or other organelles.

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  2. Does the BioTracker FAr-red Labile Fe2+ Dye stain dead or non-viable tissue, or does it exclusively stain live cells as advertised?

    1 답변

    1. SCT037, BioTracker Far Red Labile Fe2+ Dye exclusively stains live or viable cells and does not have a staining protocol for use on dead or non-viable cells. SCT037 is equivalent to FerroFarRed™ from Goryo Chemical.

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  3. Hi, I was wondering if the BioTracker Labile Iron dye # SCT037 can be freeze-thawed after being resuspended in DMSO for a second use. Also, is it fixable? Thank you.

    1 답변

    1. Storing as a solution is not recommended. In solution, the reagent degrades and the fluorescence background signal may increase.
      Yes, the FerroFarRed can be fixed under mild conditions such as 3% Paraformaldehyde for 10min at 4 °C. The fluorescence of this dye significantly diminishes when fixed in 3% PFA for 20min at RT.

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