MABS165

Anti-STAM-binding protein Antibody, clone 4D12.2

clone 4D12.2, from mouse

• 동의어(들): STAMBP, STAM-binding protein, Associated molecule with the SH3 domain of STAM, Endosome-associated ubiquitin isopeptidase, AMSH
• UNSPSC 코드: 12352203
• eCl@ss: 32160702
• NACRES: NA.41

속성

• 생물학적 소스: mouse
• Quality Level: 300
• 항체 형태: purified antibody
• 항체 생산 유형: primary antibodies
• 클론: 4D12.2, monoclonal
• 종 반응성: human
• 기술: immunocytochemistry: suitable; western blot: suitable
• 동형: IgG1κ
• NCBI 수납 번호: NP_006454
• UniProt 수납 번호: O95630
• 배송 상태: wet ice
• 타겟 번역 후 변형: unmodified
• 유전자 정보: human ... STAMBP(10617)

설명

일반 설명

STAM-binding protein (STAMBP) is a critical metalloprotease in ubiquitin-mediated signaling events that specifically cleaves ′Lys-63′-linked polyubiquitin chains but does not cleave ′Lys-48′-linked polyubiquitin chains. STAM-binding protein is a deubiquitinating (DUB) isopeptidase also known as AMSH, for associated molecule with the SH3 domain of STAM. STAM-binding protein plays a role in cell growth and MYC induction, potentiates BMP signaling and is key in regulating the cell surface receptor-mediated endocytosis and ubiquitin-dependent sorting of receptors to lysosomes. STAM-binding protein interacts with other key proteins including STAM1, SMAD6/7, SMURF2, and CHMP3. STAM-binding protein is widely expressed and can be found localized to the nucleus, cytoplasm and endosome. Defects in STAM-binding protein result in a congenital syndrome named Microcephaly-capillary malformation syndrome.

면역원

GST-tagged recombinant protein corresponding to Human STAM-binding protein.

애플리케이션

Immunocytochemistry analysis: 1:50 dilution from a representative lot detected STAM binding protein in A431 cells
DyLight^® is a trademark of Thermo Fisher Scientific, Inc. and its subsidiaries.

Research Category
Signaling

Research Sub Category
Ubiquitin & Ubiquitin Metabolism

This Anti-STAM-binding protein Antibody, clone 4D12.2 is validated for use in Western Blotting and Immunocytochemistry for the detection of STAM-binding protein.

품질

Routinely evaluated by western blotting on Jurkat cell lysate
Western Blotting Analysis: 1 µg/mL of this antibody detected STAM binding protein in 10 µg of Jurkat cell lysate

표적 설명

~50 kDa observed

물리적 형태

Format: Purified

Protein G Purified

Purified mouse monoclonal IgG1κ supernatant in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.

저장 및 안정성

Stable for 1 year at 2-8°C from date of receipt.

기타 정보

Concentration: Please refer to lot specific datasheet.

법적 정보

DyLight is a registered trademark of Pierce Biotechnology, Inc.

면책조항

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

안전성 정보

• Storage Class Code: 10 - Combustible liquids