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Merck
모든 사진(2)

주요 문서

MABN665

Sigma-Aldrich

Anti-Synaptotagmin-7 Antibody, clone N275/14

clone N275/14, from mouse

동의어(들):

Synaptotagmin-7, Synaptotagmin VII, SytVII

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모든 사진(2)

About This Item

UNSPSC 코드:
12352203
eCl@ss:
32160702
NACRES:
NA.41
제품 MABN665은(는)귀하의 국가에서 현재 판매되지 않습니다. 고객지원팀으로 연락바랍니다.

생물학적 소스

mouse

Quality Level

100

항체 형태

purified immunoglobulin

항체 생산 유형

primary antibodies

클론

N275/14, monoclonal

종 반응성

mouse, human, rat

기술

immunohistochemistry: suitable
western blot: suitable

동형

IgG2bκ

NCBI 수납 번호

NP_061271

UniProt 수납 번호

Q9R0N7

배송 상태

wet ice

타겟 번역 후 변형

unmodified

유전자 정보

human ... SYT7(9066)

일반 설명

Synaptotagmin-7 is also referred to as Synaptotagmin VII (SytVII) and is a member of the synaptotagmin family of transmembrane transporters. Synaptotagmin-7 is involved in plasma membrane repair, and possibly Ca2+-dependent exocytosis and traffiking of secretory vesicles.

특이성

This antibody recognizes the cytoplasmic C2A domain of Synaptotagmin-7. This antibody does not cross react with Synaptotagmin-6 or other Synaptotagmins (Prof. J. Trimmer, University of California, Davis.).

면역원

Epitope: Cytoplasmic C2A domain
Recombinant protein corresponding to the cytoplasmic C2A domain of mouse Synaptotagmin-7.

애플리케이션

Anti-Synaptotagmin-7 Antibody, clone N275/14 is a highly specific mouse monoclonal antibody, that targets Synaptotagmin & has been tested in western blotting & IHC.
Immunohistochemistry Analysis: A 1:50 dilution from a representative lot detected Synaptotagmin-7 in human thalamus tissue.
Research Category
Neuroscience
Research Sub Category
Developmental Signaling

품질

Evaluated by Western Blotting in mouse brain tissue lysate.

Western Blotting Analysis: 0.5 µg/mL of this antibody detected Synaptotagmin-7 in 10 µg of mouse brain tissue lysate.

표적 설명

~ 45 kDa observed. Uncharacterized band(s) may appear in some lysates.

물리적 형태

Format: Purified
Protein G Purified
Purified mouse monoclonal IgG2bκ in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.

저장 및 안정성

Stable for 1 year at 2-8°C from date of receipt.

분석 메모

Control
Mouse brain tissue lysate

기타 정보

Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.

면책조항

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Storage Class Code

12 - Non Combustible Liquids

WGK

WGK 1

Flash Point (°F)

Not applicable

Flash Point (°C)

Not applicable

시험 성적서(COA)

제품의 로트/배치 번호를 입력하여 시험 성적서(COA)을 검색하십시오. 로트 및 배치 번호는 제품 라벨에 있는 ‘로트’ 또는 ‘배치’라는 용어 뒤에서 찾을 수 있습니다.

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문서 라이브러리 방문

Gaël Barthet et al.
Nature communications, 9(1), 4780-4780 (2018-11-16)
Mutations of the intramembrane protease presenilin (PS) or of its main substrate, the amyloid precursor protein (APP), cause early-onset form of Alzheimer disease. PS and APP interact with proteins of the neurotransmitter release machinery without identified functional consequences. Here we
Christopher Weyrer et al.
Cell reports, 36(12), 109719-109719 (2021-09-23)
Synaptotagmin 7 (Syt7) is a high-affinity calcium sensor that is implicated in multiple aspects of synaptic transmission. Here, we study the influence of Syt7 on the climbing fiber (CF) to Purkinje cell (PC) synapse. We find that small facilitation and
Synaptotagmin-7 Enhances Facilitation of Cav2.1 Calcium Channels.
Djillani, et al.
eNeuro, 9 (2023)
Bassam Tawfik et al.
eLife, 10 (2021-03-23)
Synaptotagmins confer calcium-dependence to the exocytosis of secretory vesicles, but how coexpressed synaptotagmins interact remains unclear. We find that synaptotagmin-1 and synaptotagmin-7 when present alone act as standalone fast and slow Ca2+-sensors for vesicle fusion in mouse chromaffin cells. When
Katarina Trajkovic et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience, 37(37), 9000-9012 (2017-08-20)
Huntington's disease (HD) is an autosomal-dominant neurodegenerative disorder caused by the expansion of a CAG triplet in the gene encoding for huntingtin (Htt). The resulting mutant protein (mHtt) with extended polyglutamine (polyQ) sequence at the N terminus leads to neuronal

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