This product is carrier-free and does not contain glycerol, gelatin, or serum albumin. The antibody has not been tested for the suitability in Hyperion imaging application. The end-user will have to determine the suitability.
제품 MABC539은(는)귀하의 국가에서 현재 판매되지 않습니다. 고객지원팀으로 연락바랍니다.
추천 제품
생물학적 소스
mouse
Quality Level
항체 형태
purified antibody
항체 생산 유형
primary antibodies
클론
80.8.6, monoclonal
종 반응성
human
기술
immunohistochemistry: suitable
inhibition assay: suitable
동형
IgG2aκ
NCBI 수납 번호
UniProt 수납 번호
배송 상태
wet ice
타겟 번역 후 변형
unmodified
유전자 정보
human ... SFRP2(6423)
일반 설명
Secreted frizzled-related proteins (SFRPs) may play a critical role in carcinogenesis by inhibiting the Wnt/beta-catenin signaling pathway. Secreted frizzled-related protein 2 (SFRP2) may be useful to further investigate mammary tumorigenesis as its expression increases with tumor progression in canine mammary gland tumors. SFRP2 in mouse embryos has been found to cause severe shortening of the thoracic region. Studies have shown that this protein is the essential stem cell paracrine factor that is thought to regulate myocardial survival and repair damage in the aftermath of an ischemic injury.
면역원
Epitope: NTR domain
Linear peptide corresponding to the NTR domain of human SFRP2.
애플리케이션
Anti-SFRP2 Antibody, clone 80.8.6, azide free is an antibody against SFRP2 for use in IHC & inhibition.
Inhibition Assay Analysis: Anti-SFRP2, clone 80.8.6 inhibits tube formation and cell migration in vitro on SVR angiosarcoma cells, inhibits angiosarcoma and breast cancer growth in vivo, and increases nuclear NFATc3 levels.
품질
Evaluated by Immunohistochemistry in human prostate and human breast cancer tissue.
Imunnohistochemistry Analysis: A 1:500 dilution of this antibody detected SFRP2 in human prostate and human breast cancer tissue.
Imunnohistochemistry Analysis: A 1:500 dilution of this antibody detected SFRP2 in human prostate and human breast cancer tissue.
표적 설명
33 kDa calculated
물리적 형태
Format: Purified
기타 정보
Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.
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Storage Class Code
12 - Non Combustible Liquids
WGK
WGK 2
Flash Point (°F)
Not applicable
Flash Point (°C)
Not applicable
시험 성적서(COA)
제품의 로트/배치 번호를 입력하여 시험 성적서(COA)을 검색하십시오. 로트 및 배치 번호는 제품 라벨에 있는 ‘로트’ 또는 ‘배치’라는 용어 뒤에서 찾을 수 있습니다.
Amanpreet Kaur et al.
Nature, 532(7598), 250-254 (2016-04-05)
Cancer is a disease of ageing. Clinically, aged cancer patients tend to have a poorer prognosis than young. This may be due to accumulated cellular damage, decreases in adaptive immunity, and chronic inflammation. However, the effects of the aged microenvironment
Mitchell E Fane et al.
Clinical cancer research : an official journal of the American Association for Cancer Research, 26(21), 5709-5719 (2020-10-25)
Angiogenesis is thought to be critical for tumor metastasis. However, inhibiting angiogenesis using antibodies such as bevacizumab (Avastin), has had little impact on melanoma patient survival. We have demonstrated that both angiogenesis and metastasis are increased in older individuals, and
Y Sun et al.
Oncogene, 35(33), 4321-4334 (2016-01-12)
Most tumors initially respond to cytotoxic treatments, but acquired resistance often follows. The tumor microenvironment (TME) is a major barrier to clinical success by compromising therapeutic efficacy, and pathological relevance of multiple soluble factors released by a therapeutically remodeled TME
활성 필터
자사의 과학자팀은 생명 과학, 재료 과학, 화학 합성, 크로마토그래피, 분석 및 기타 많은 영역을 포함한 모든 과학 분야에 경험이 있습니다..
고객지원팀으로 연락바랍니다.
