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Merck
모든 사진(1)

주요 문서

MAB5430

Sigma-Aldrich

Anti-Tau Antibody, Caspase Cleaved (truncated at Asp421)

clone tau-C3, Chemicon®, from mouse

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About This Item

UNSPSC 코드:
12352203
eCl@ss:
32160702
NACRES:
NA.41

생물학적 소스

mouse

Quality Level

항체 형태

purified immunoglobulin

항체 생산 유형

primary antibodies

클론

tau-C3, monoclonal

종 반응성

human

제조업체/상표

Chemicon®

기술

ELISA: suitable
immunohistochemistry: suitable
western blot: suitable

동형

IgG1

UniProt 수납 번호

배송 상태

wet ice

타겟 번역 후 변형

unmodified

유전자 정보

human ... MAPT(4137)

특이성

Reacts with Tau, caspase cleaved (truncated at Asp421). The antibody shows no reactivity with full length tau nor other tau C-terminal truncations. The antibody stains amyloid beta treated neurons and brain tissue in Alzheimer′s disease, more specifically it stains a subset of neurofibrillary tangles, tau-containing neuritic plaques and neuropil threads.

면역원

Epitope: Caspase Cleaved (truncated at Asp421)
Peptide corresponding to the C-terminus of tau truncated as aspartic acid 421.

애플리케이션

Anti-Tau Antibody, Caspase Cleaved (truncated at Asp421) is an antibody against Tau for use in ELISA, WB, IH.
Research Category
Neuroscience
Research Sub Category
Neurodegenerative Diseases
Western blot

Immunohistochemistry

ELISA

Optimal working dilutions must be determined by end user.

표적 설명

43 kDa (aa 1 to 421) or smaller fragments with Asp421 as the c-terminus

물리적 형태

Format: Purified
Purified immunoglobulin. Liquid in PBS. Contains no preservative.

저장 및 안정성

Maintain at 2-8°C in undiluted aliquots for up to 6 months after date of receipt.

기타 정보

Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.

법적 정보

CHEMICON is a registered trademark of Merck KGaA, Darmstadt, Germany

면책조항

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Storage Class Code

10 - Combustible liquids

WGK

WGK 2

Flash Point (°F)

Not applicable

Flash Point (°C)

Not applicable


시험 성적서(COA)

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문서 라이브러리 방문

Patrice Delobel et al.
The American journal of pathology, 172(1), 123-131 (2007-12-15)
Recent evidence has suggested that truncation of tau protein at the caspase cleavage site D421 precedes hyperphosphorylation and may be necessary for the assembly of tau into filaments in Alzheimer's disease and other tauopathies. Here we have investigated the time
Debra K Kumasaka et al.
International journal of physiology, pathophysiology and pharmacology, 1(1), 48-56 (2009-01-12)
A recent study demonstrated the lack of beta-amyloid (Abeta) plaque formation and accumulation of the amyloid precursor protein (APP) in a triple transgenic mouse model of Alzheimer's disease (3xTg-AD) following overexpression of the anti-apoptotic protein, Bcl-2 (Rohn et al., J.
Tau pathogenesis is promoted by A?1-42 but not A?1-40.
Hu, X; Li, X; Zhao, M; Gottesdiener, A; Luo, W; Paul, S
Mol. Neurodegener. null
Mariko Saito et al.
Neurochemical research, 35(4), 651-659 (2010-01-06)
Previous studies indicated that ethanol-induced neurodegeneration in postnatal day 7 (P7) mice, widely used as a model for the fetal alcohol spectrum disorders, was accompanied by glycogen synthase kinase-3beta (GSK-3beta) and caspase-3 activation. Presently, we examined whether tau, a microtubule
John C Means et al.
Cellular and molecular neurobiology, 40(6), 911-926 (2020-01-11)
Optic nerve head astrocytes (ONHAs) are the major cell type within the optic nerve head, providing both structural and nutrient support to the optic nerve. Astrocytes are necessary for the survival of neurons with controlled activation of astrocytes being beneficial

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