추천 제품
생물학적 소스
mouse
Quality Level
항체 형태
purified immunoglobulin
항체 생산 유형
primary antibodies
클론
tau-C3, monoclonal
종 반응성
human
제조업체/상표
Chemicon®
기술
ELISA: suitable
immunohistochemistry: suitable
western blot: suitable
동형
IgG1
UniProt 수납 번호
배송 상태
wet ice
타겟 번역 후 변형
unmodified
유전자 정보
human ... MAPT(4137)
특이성
Reacts with Tau, caspase cleaved (truncated at Asp421). The antibody shows no reactivity with full length tau nor other tau C-terminal truncations. The antibody stains amyloid beta treated neurons and brain tissue in Alzheimer′s disease, more specifically it stains a subset of neurofibrillary tangles, tau-containing neuritic plaques and neuropil threads.
면역원
Epitope: Caspase Cleaved (truncated at Asp421)
Peptide corresponding to the C-terminus of tau truncated as aspartic acid 421.
애플리케이션
Anti-Tau Antibody, Caspase Cleaved (truncated at Asp421) is an antibody against Tau for use in ELISA, WB, IH.
Research Category
Neuroscience
Neuroscience
Research Sub Category
Neurodegenerative Diseases
Neurodegenerative Diseases
Western blot
Immunohistochemistry
ELISA
Optimal working dilutions must be determined by end user.
Immunohistochemistry
ELISA
Optimal working dilutions must be determined by end user.
표적 설명
43 kDa (aa 1 to 421) or smaller fragments with Asp421 as the c-terminus
물리적 형태
Format: Purified
Purified immunoglobulin. Liquid in PBS. Contains no preservative.
저장 및 안정성
Maintain at 2-8°C in undiluted aliquots for up to 6 months after date of receipt.
기타 정보
Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.
법적 정보
CHEMICON is a registered trademark of Merck KGaA, Darmstadt, Germany
면책조항
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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Storage Class Code
10 - Combustible liquids
WGK
WGK 2
Flash Point (°F)
Not applicable
Flash Point (°C)
Not applicable
시험 성적서(COA)
제품의 로트/배치 번호를 입력하여 시험 성적서(COA)을 검색하십시오. 로트 및 배치 번호는 제품 라벨에 있는 ‘로트’ 또는 ‘배치’라는 용어 뒤에서 찾을 수 있습니다.
The American journal of pathology, 172(1), 123-131 (2007-12-15)
Recent evidence has suggested that truncation of tau protein at the caspase cleavage site D421 precedes hyperphosphorylation and may be necessary for the assembly of tau into filaments in Alzheimer's disease and other tauopathies. Here we have investigated the time
International journal of physiology, pathophysiology and pharmacology, 1(1), 48-56 (2009-01-12)
A recent study demonstrated the lack of beta-amyloid (Abeta) plaque formation and accumulation of the amyloid precursor protein (APP) in a triple transgenic mouse model of Alzheimer's disease (3xTg-AD) following overexpression of the anti-apoptotic protein, Bcl-2 (Rohn et al., J.
Tau pathogenesis is promoted by A?1-42 but not A?1-40.
Mol. Neurodegener. null
Tau phosphorylation and cleavage in ethanol-induced neurodegeneration in the developing mouse brain.
Neurochemical research, 35(4), 651-659 (2010-01-06)
Previous studies indicated that ethanol-induced neurodegeneration in postnatal day 7 (P7) mice, widely used as a model for the fetal alcohol spectrum disorders, was accompanied by glycogen synthase kinase-3beta (GSK-3beta) and caspase-3 activation. Presently, we examined whether tau, a microtubule
Cellular and molecular neurobiology, 40(6), 911-926 (2020-01-11)
Optic nerve head astrocytes (ONHAs) are the major cell type within the optic nerve head, providing both structural and nutrient support to the optic nerve. Astrocytes are necessary for the survival of neurons with controlled activation of astrocytes being beneficial
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