추천 제품
제품명
Anti-Chondroitin Sulfate Proteoglycan Antibody, Brain (core protein), clone Cat-301, clone Cat-301, Chemicon®, from mouse
생물학적 소스
mouse
Quality Level
항체 형태
purified immunoglobulin
항체 생산 유형
primary antibodies
클론
Cat-301, monoclonal
종 반응성
primate, human, rat, gerbil, feline, hamster, guinea pig
제조업체/상표
Chemicon®
기술
immunocytochemistry: suitable
immunohistochemistry: suitable
immunoprecipitation (IP): suitable
western blot: suitable
동형
IgG1
NCBI 수납 번호
UniProt 수납 번호
배송 상태
wet ice
타겟 번역 후 변형
unmodified
유전자 정보
human ... ACAN(176)
일반 설명
The antigen recognized by this clone, CAT-301 is a proteoglycan that is developmentaly regulated, high molecular chondroitin sulphate proteoglycan found on the extracellular surface of mammalian neurons. It is expressed late in development and although no definitive role has been identified for CAT-301, it is believed to have a role in the stabilisation of synaptic structure.
The name derives from the name of the monoclonal antibody originally used to identified by its expression, which was detected immunocytochemicaly
Disruption of the normal patterns of neuronal activity during the critical early postnatal period by physical or biochemical means results in a large and irreversible reduction in levels of CAT-301. Similar intervention in mature animals has no effect
CAT-301 is related to aggrecan from articular cartilage. The CAT-301 antibody immunoreacts with aggrecan, and the chondroitinase treated aggrecan and CAT-301 both have apparent sizes of 550kDa. However CAT- 301 is not glycosylated by keratan sulphate, as aggrecan is.
The name derives from the name of the monoclonal antibody originally used to identified by its expression, which was detected immunocytochemicaly
Disruption of the normal patterns of neuronal activity during the critical early postnatal period by physical or biochemical means results in a large and irreversible reduction in levels of CAT-301. Similar intervention in mature animals has no effect
CAT-301 is related to aggrecan from articular cartilage. The CAT-301 antibody immunoreacts with aggrecan, and the chondroitinase treated aggrecan and CAT-301 both have apparent sizes of 550kDa. However CAT- 301 is not glycosylated by keratan sulphate, as aggrecan is.
특이성
Chondroitin sulfate proteoglycan (CSPG), brain core protein.
면역원
Epitope: Brain (core protein)
Feline spinal cord fixed gray matter.
애플리케이션
Anti-Chondroitin Sulfate Proteoglycan Antibody, Brain (core protein), clone Cat-301 detects level of Chondroitin Sulfate Proteoglycan & has been published & validated for use in IP, WB, IC, IH.
Immunohistochemistry: 1:500-1:2,000 on 4% paraformaldehyde fixed frozen tissue.
Immunocytochemistry
Immunoblot
Immunoprecipitation
Optimal working dilutions must be determined by the end user.
Immunocytochemistry
Immunoblot
Immunoprecipitation
Optimal working dilutions must be determined by the end user.
물리적 형태
Format: Purified
기타 정보
Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.
법적 정보
CHEMICON is a registered trademark of Merck KGaA, Darmstadt, Germany
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Storage Class Code
10 - Combustible liquids
WGK
WGK 2
Flash Point (°F)
Not applicable
Flash Point (°C)
Not applicable
시험 성적서(COA)
제품의 로트/배치 번호를 입력하여 시험 성적서(COA)을 검색하십시오. 로트 및 배치 번호는 제품 라벨에 있는 ‘로트’ 또는 ‘배치’라는 용어 뒤에서 찾을 수 있습니다.
Maija-Kreetta Koskinen et al.
Scientific reports, 10(1), 17308-17308 (2020-10-16)
Stress can predispose to depressive episodes, yet the molecular mechanisms regulating the transition from the initial stress response to a persistent pathological depressive state remain poorly understood. We profiled the development of an enduring depressive-like state by assessing affective behavior
Juhwan Kim et al.
Scientific reports, 8(1), 9839-9839 (2018-07-01)
The failure of mature central nervous system (CNS) projection neurons to regenerate axons over long distances drastically limits the recovery of functions lost after various CNS injuries and diseases. Although a number of manipulations that stimulate some degree of axon
Otavio S C Mariani et al.
The Journal of comparative neurology, 527(3), 694-717 (2018-03-27)
We propose a partitioning of the primate intraparietal sulcus (IPS) using immunoarchitectural and connectivity criteria. We studied the immunoarchitecture of the IPS areas in the capuchin monkey using Cat-301 and SMI-32 immunohistochemistry. In addition, we investigated the IPS projections to
Lena Iwai et al.
Cerebral cortex (New York, N.Y. : 1991), 23(9), 2204-2212 (2012-07-14)
Although the parallel visual pathways are a fundamental basis of visual processing, our knowledge of their molecular properties is still limited. Here, we uncovered a parvocellular-specific molecule in the dorsal lateral geniculate nucleus (dLGN) of higher mammals. We found that
Vasily Vorobyov et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience, 33(1), 234-243 (2013-01-04)
Monocular deprivation (MD) during a critical period of postnatal development produces significant changes in the anatomy and physiology of the visual cortex, and the deprived eye becomes amblyopic. Extracellular matrix molecules have a major role in restricting plasticity such that
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