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Merck
모든 사진(1)

주요 문서

FCMAB314F

Sigma-Aldrich

Milli-Mark Anti-CNPase-FITC Antibody, clone 11-5B

clone 11-5B, Milli-Mark®, from mouse

동의어(들):

2′3′-Cyclic Nucleotide 3′-Phosphohydrolase

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About This Item

UNSPSC 코드:
12352203
eCl@ss:
32160702
NACRES:
NA.41
결합:
FITC conjugate
application:
FACS
클론:
11-5B, monoclonal
종 반응성:
human
citations:
기술:
flow cytometry: suitable

생물학적 소스

mouse

Quality Level

결합

FITC conjugate

항체 형태

purified antibody

항체 생산 유형

primary antibodies

클론

11-5B, monoclonal

종 반응성

human

제조업체/상표

Milli-Mark®

기술

flow cytometry: suitable

동형

IgG1

NCBI 수납 번호

UniProt 수납 번호

배송 상태

wet ice

타겟 번역 후 변형

unmodified

유전자 정보

human ... CNP(1267)

관련 카테고리

일반 설명

CNPase (2′, 3′-cyclic nucleotide 3′-phosphodiesterase [or -phosphohydrolase], EC 3.1.4.37) is present in very high levels in brain and peripheral nerve. This enzyme is found almost exclusively in oligo-dendrocytes and Schwann cells, the cells that form myelin in the central and peripheral nervous system, respectively.
Immunohistochemical localization of CNPase has shown the enzyme to be restricted to oligodendrocytes and Schwann cells. The enzyme appears to be distributed in single and double loose wraps of myelin and not in compact myelin as earlier thought by most investigators. CNPase is located on the inner and outer loops of myelin, paranodally and near the inner surface of the oligodendrocyte membrane. In plaque regions of multiple sclerosis patients, the enzyme is reduced, and when CNS myelin is decreased, CNPase is one of the earlier proteins to be lost from the myelin. In addition, an enzyme that is probably identical to brain CNPase is located in the outer rod segments within the visual system, and this protein is also recognized by the monoclonal antibody 11-5B. In mixed human gliomas, the enzyme levels are reduced, although about 5% of the oligodendrocytes occasionally show normal positive staining.

특이성

Antibody recognizes Human CNPase protein.

면역원

Purified human brain CNPase protein.

애플리케이션

Detect CNPase using this Milli-Mark Anti-CNPase-FITC Antibody, clone 11-5B validated for use in FC.
Research Category
Neuroscience
Research Sub Category
Neuronal & Glial Markers

품질

Evaluated by flow cytometry using U251 Cells.

표적 설명

48kDa Calculated

물리적 형태

Protein A purified
Purified mouse monoclonal IgG1 conjugated to FITC in PBS with 0.1% sodium azide and 15 mg/mL BSA.

저장 및 안정성

Maintain refrigerated at 2-8 °C protected from light in undiluted aliquots for up to 6 months from date of receipt.

분석 메모

Control
U251 Cells

법적 정보

MILLI-MARK is a registered trademark of Merck KGaA, Darmstadt, Germany

면책조항

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Storage Class Code

10 - Combustible liquids

WGK

WGK 2

Flash Point (°F)

Not applicable

Flash Point (°C)

Not applicable


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