CH2900010

Calcium Folinate Hydrate amorphous / Leucovorin Calcium amorphous

USP, Ph. Eur.

• 동의어(들): Folinic acid calcium salt, Calcii Folinas, Calcium Folinate, Leucovorin Calcium, Calcium folinate
• 실험식(Hill 표기법): C₂₀H₂₁CaN₇O₇
• CAS Number: 1492-18-8
• Molecular Weight: 511.50
• MDL number: MFCD00006704
• UNSPSC 코드: 41116107

속성

• 생물학적 소스: synthetic
• Quality Level: 600
• Grade: GMO free; GMP; Halal; Kosher
• Agency: Ph. Eur.; USP
• 양식: powder
• 응용 분야: liquid formulation; pharmaceutical
• 저장 온도: 2-8°C
• SMILES string: [Ca+2].[nH]1c2c([c](nc1N)=O)N(C(CN2)CNc3ccc(cc3)C(=O)N[C@@H](CCC(=O)[O-])C(=O)[O-])C=O
• InChI: 1S/C20H23N7O7.Ca/c21-20-25-16-15(18(32)26-20)27(9-28)12(8-23-16)7-22-11-3-1-10(2-4-11)17(31)24-13(19(33)34)5-6-14(29)30;/h1-4,9,12-13,22H,5-8H2,(H,24,31)(H,29,30)(H,33,34)(H4,21,23,25,26,32);/q;+2/p-2/t12?,13-;/m0./s1
• InChI key: KVUAALJSMIVURS-ZEDZUCNESA-L

설명

일반 설명

We provide industry-leading production know-how and comprehensive regulatory support for high-quality APIs, backed by nearly 200 years of experience. From a complete portfolio of innovative folates to custom synthesis, our customized and scalable solutions meet your specific production needs. Our SAFC^® portfolio of high-quality products for biopharmaceutical and pharmaceutical formulation and production withstands strict quality control procedures and is produced according to applicable cGMP guidelines.

애플리케이션

Calcium Folinate Hydrate amorphous has three main clinical applications:
1) First line treatment for colorectal cancer: In combination with the anticancer drug 5-fluorouracil (5-FU), Irinotecan, Cisplatin or Oxaliplatin, and its derivatives. Calcium Folinate is a modulator of 5-FU and enhances its efficacy in cancer chemotherapy.
2) Treatment of certain neoplastic diseases, severe psoriasis, and adult rheumatoid arthritis as a rescue therapy to reduce the toxic side effects of intermediate or high doses of methotrexate.
3) Treatment of anemia caused by folate deficiency.

포장

Customized packaging possible

법적 정보

SAFC is a registered trademark of Merck KGaA, Darmstadt, Germany

안전성 정보

• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 1
• Flash Point (°F): Not applicable
• Flash Point (°C): Not applicable