ABT404

Anti-CAPN6 Antibody

from rabbit, purified by affinity chromatography

• 동의어(들): Calpain-6, Calpain-like protease X-linked, Calpamodulin, CalpM
• UNSPSC 코드: 12352203
• eCl@ss: 32160702
• NACRES: NA.41

속성

• 생물학적 소스: rabbit
• 항체 형태: affinity isolated antibody
• 항체 생산 유형: primary antibodies
• 클론: polyclonal
• 정제법: affinity chromatography
• 종 반응성: rat, human
• 기술: immunofluorescence: suitable; immunohistochemistry: suitable; western blot: suitable
• UniProt 수납 번호: Q9Y6Q1
• 배송 상태: wet ice
• 타겟 번역 후 변형: unmodified
• 유전자 정보: human ... CAPN6(827)

설명

일반 설명

Calpain-6, also known as Calpain-like protease X-linked or Calpamodulin (CalpM) and encoded by the gene name CAPN6 or CALPM, belongs to a well-conserved family of calcium-dependent cysteine proteases. The calpain proteins are heterodimers consisting of an invariant small subunit and variable large subunits. This large subunit possesses a cysteine protease domain, and both subunits possess calcium-binding domains. Calpains have been implicated in neurodegenerative processes as their activation can be triggered by calcium influx and oxidative stress. CAPN6 is most similar to Calpain 5; the C-terminal region of CAPN6 lacks homology to the calmodulin like domain of other vertebrate calpains. CAPN6 is thought to be involved in the regulation of microtubule dynamics and cytoskeletal organization. CAPN6 has also been recently identified as an HIV dependency factor (HDF), suggesting that CAPN6 may be an important drug target in HIV treatment.

면역원

Epitope: C-terminus

KLH-conjugated synthetic peptide corresponding to the C-terminus of human CAPN6.

애플리케이션

Anti-CAPN6 Antibody is an antibody against CAPN6 for use in western blotting, IHC & immunofluorescence.

Immunohistochemistry Analysis: 2.5 μg/mL from a representative lot detected CAPN6 in human lung tissue.

Immunofluorescence Analysis: 20 μg/mL from a representative lot detected CAPN6 in human lung cells.

Research Category
Cell Structure

Research Sub Category
Cytoskeleton

품질

Evaluated by Western Blotting in rat lung tissue lysate.

Western Blotting Analysis: 1 μg/mL of this antibody detected CAPN6 in rat lung tissue lysate.

표적 설명

~75 kDa observed. Uncharacterized bands may be observed in some lysate(s).

물리적 형태

Antigen Affinity Purified

Purified rabbit polyclonal in buffer containing PBS with up to 0.1% sodium azide.

저장 및 안정성

Stable for 1 year at 2-8°C from date of receipt.

기타 정보

Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.

면책조항

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

안전성 정보

• Storage Class Code: 10 - Combustible liquids
• WGK: WGK 2
• Flash Point (°F): Not applicable
• Flash Point (°C): Not applicable