ABT165

Anti-RAB8A Antibody

from rabbit, purified by affinity chromatography

• 동의어(들): Ras-related protein Rab-8A, Oncogene c-mel
• UNSPSC 코드: 12352203
• eCl@ss: 32160702
• NACRES: NA.41

속성

• 생물학적 소스: rabbit
• Quality Level: 100
• 항체 형태: affinity isolated antibody
• 항체 생산 유형: primary antibodies
• 클론: polyclonal
• 정제법: affinity chromatography
• 종 반응성: human
• 종 반응성(상동성에 의해 예측): mouse (based on 100% sequence homology), bovine (based on 100% sequence homology)
• 기술: western blot: suitable
• NCBI 수납 번호: NP_005361
• UniProt 수납 번호: P61006
• 배송 상태: wet ice
• 타겟 번역 후 변형: unmodified
• 유전자 정보: human ... RAB8A(4218) ; mouse ... Rab8A(17274)

설명

일반 설명

Ras-related protein Rab-8A (RAB8A) is one of two Rab8 isoforms, which belong to the superfamily of GTPases. They cycle between an active GTP-bound state, formed from interaction with guanine nucleotide exchange factors (GEFs) such as Rabin8 and GRAB; and an inactive GDP-bound state via interaction with GTPase activating proteins (GAPs) such as TBC1D1. Rab8A activates various effector molecules, which are coupled to intracellular signaling networks that mediate membrane and vesicular trafficking, and actin remodeling. Rab8A is found in the golgi network, perinuclear region, plasma membrane, lamellipodia, and cilia, among other regions.

특이성

This antibody recognizes the C-terminus of RAB8A.

면역원

Epitope: C-terminus

KLH-conjugated linear peptide corresponding to the C-terminus of human RAB8A.

애플리케이션

Research Category
Cell Structure

Research Sub Category
Vesicular Trafficking

This Anti-RAB8A Antibody is validated for use in Western Blotting for the detection of RAB8A.

Western Blot Analysis: A representative lot from an independent laboratory detected RAB8A in human cerebellum and brain.

품질

Evaluated by Western Blot in serum starved HeLa cell lysate.

Western Blot Analysis: 1 µg/mL of this antibody detected RAB8A in serum starved HeLa cell lysate.

표적 설명

~24 kDa observed. Uncharacterized bands may be observed at ~110 kDa and ~38 kDa

물리적 형태

Affinity purified

Purified rabbit polyclonal in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.

저장 및 안정성

Stable for 1 year at 2-8°C from date of receipt.

분석 메모

Control
Serum starved HeLa cell lysate

기타 정보

Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.

면책조항

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

안전성 정보

• Storage Class Code: 12 - Non Combustible Liquids
• WGK: WGK 1
• Flash Point (°F): Not applicable
• Flash Point (°C): Not applicable