ABN1456

Anti-IAPP

from rabbit, purified by affinity chromatography

• 동의어(들): Amylin, Diabetes associated peptide, DAP, Insulinoma amyloid peptide
• UNSPSC 코드: 12352203
• eCl@ss: 32160702
• NACRES: NA.41

속성

• 생물학적 소스: rabbit
• Quality Level: 100
• 항체 형태: affinity isolated antibody
• 항체 생산 유형: primary antibodies
• 클론: polyclonal
• 정제법: affinity chromatography
• 종 반응성: human
• 기술: immunohistochemistry: suitable (paraffin)
• NCBI 수납 번호: NP_000406
• UniProt 수납 번호: P10997
• 배송 상태: ambient
• 타겟 번역 후 변형: unmodified
• 유전자 정보: human ... IAPP(3375)

설명

일반 설명

Islet amyloid polypeptide (UniProt: P10997; also known as Amylin; Diabetes-associated peptide; DAP; Insulinoma amyloid peptide, IAPP) is encoded by the IAPP gene (Gene ID: 3375) in human. IAPP is a secreted peptide that is degraded by insulin degrading enzyme (IDE). IAPP is a major constituent of amyloid deposits in pancreatic islets, characteristic histopathology for type 2 diabetes. The mature IAPP is largely unstructured in the absence of a cognate ligand, and has a strong tendency to form fibrillar aggregates. In diabetic islets, water-soluble IAPP is shown to disappear in beta-cell granules and is transformed to water-insoluble amyloid deposits that can initiate beta cell necrosis. Oligomers of human IAPP can form toxic oligomers and induce apoptosis in cultured pancreatic cells. IAPP is shown to selectively inhibit insulin-stimulated glucose utilization and glycogen deposition in muscle, but does not affect adipocyte glucose metabolism. (Ref.: Bram, Y., et al. (2014). Scientific Reports 4, Article number: 4267; Tomita, T. (2012). Islets. 4(3): 223 232).

특이성

This polyclonal antibody detects IAPP in human pancreatic tissue.

면역원

A KLH-conjugated linear peptide from an internal region of human islet amyloid polypeptide.

애플리케이션

Anti-IAPP, Cat. No. ABN1456, is a highly specific rabbit polyclonal antibody that targets Islet amyloid polypeptide and has been tested in Immunohistochemistry (Paraffin).

품질

Evaluated by Immunohistochemistry in human pancreas tissue.

Immunohistochemistry Analysis: A 1:50 dilution of this antibody detected IAPP in human pancreas tissue.

표적 설명

9.8 kDa calculated

기타 정보

Concentration: Please refer to lot specific datasheet.

안전성 정보

• Storage Class Code: 12 - Non Combustible Liquids
• WGK: WGK 1