추천 제품
일반 설명
Oligodendrocyte transcription factor 2 (OLIG2), also known as Oligodendrocyte transcription factor 2 Oligo2, Class B basic helix-loop-helix protein 1 (bHLHb1), Class E basic helix-loop-helix protein 19 (bHLHe19), Protein kinase C-binding protein 2, Protein kinase C-binding protein RACK17, is encoded by the gene name OLIG2/ BHLHB1/ BHLHE19/ PRKCBP2/ RACK17. Olig2 is required for oligodendrocyte and motor neuron specification in the spinal cord, as well as for the development of somatic motor neurons in the hindbrain. It cooperates with OLIG1 to establish the pMN domain of the embryonic neural tube. Olig2 is an antagonist of V2 interneuron and of NKX2-2-induced V3 interneuron development. The restricted expression of Olig2 in oligodendrocytes makes AB9610 an excellent marker of oligodendroglia and oligodendrogliomas in development and mature systems. Olig2 is expressed in the brain and oligodendrocytes. Olig2 is strongly expressed in oligodendrogliomas, while expression is weak to moderate in astrocytomas. Expression in glioblastomas highly variable.
면역원
Epitope: Unknown
KLH-conjugated linear peptide corresponding to mouse Oligodendrocyte transcription factor 2 (OLIG2).
애플리케이션
Immunohistochemistry Analysis: A 1:250 dilution from a representative lot detected Oligodendrocyte transcription factor 2 (OLIG2) in human cortical brain section tissue.
Research Category
Neuroscience
Neuroscience
Research Sub Category
Developmental Signaling
Developmental Signaling
This Anti-Oligodendrocyte transcription factor 2 (OLIG2 antibody is validated for use in WB, IH(P) for the detection of Oligodendrocyte transcription factor 2 (OLIG2.
품질
Evaluated by Western Blotting in mouse brain tissue lysate.
Western Blotting Analysis: A 1:1;000 dilution of this antibody detected Oligodendrocyte transcription factor 2 (OLIG2) in 10 µg of mouse brain tissue lysate.
Western Blotting Analysis: A 1:1;000 dilution of this antibody detected Oligodendrocyte transcription factor 2 (OLIG2) in 10 µg of mouse brain tissue lysate.
표적 설명
~37 kDa observed
물리적 형태
Guinea pig polyclonal serum with 0.05% sodium azide.
Unpurified
저장 및 안정성
Stable for 1 year at -20°C from date of receipt.
Handling Recommendations: Upon receipt and prior to removing the cap, centrifuge the vial and gently mix the solution. Aliquot into microcentrifuge tubes and store at -20°C. Avoid repeated freeze/thaw cycles, which may damage IgG and affect product performance.
Handling Recommendations: Upon receipt and prior to removing the cap, centrifuge the vial and gently mix the solution. Aliquot into microcentrifuge tubes and store at -20°C. Avoid repeated freeze/thaw cycles, which may damage IgG and affect product performance.
기타 정보
Concentration: Please refer to lot specific datasheet.
면책조항
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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Storage Class Code
10 - Combustible liquids
WGK
WGK 1
시험 성적서(COA)
제품의 로트/배치 번호를 입력하여 시험 성적서(COA)을 검색하십시오. 로트 및 배치 번호는 제품 라벨에 있는 ‘로트’ 또는 ‘배치’라는 용어 뒤에서 찾을 수 있습니다.
Timothy M O'Shea et al.
Nature neuroscience, 27(8), 1505-1521 (2024-06-22)
Central nervous system (CNS) lesions become surrounded by neuroprotective borders of newly proliferated reactive astrocytes; however, fundamental features of these cells are poorly understood. Here we show that following spinal cord injury or stroke, 90% and 10% of border-forming astrocytes
Marc Oria et al.
Frontiers in molecular neuroscience, 15, 888351-888351 (2022-07-06)
During embryonic spinal cord development, neural progenitor cells (NPCs) generate three major cell lines: neurons, oligodendrocytes, and astrocytes at precise times and locations within the spinal cord. Recent studies demonstrate early astrogenesis in animal models of spina bifida, which may
Michaela Fredrich et al.
Hippocampus, 27(5), 495-506 (2017-01-19)
The hippocampus is subjected to diurnal/circadian rhythms on both the morphological and molecular levels. Certain aspects of cell proliferation in the adult hippocampus are regulated by melatonin and accompanied by apoptosis to ensure proper tissue maintenance and function. The present
Marina Bershteyn et al.
Cell stem cell, 30(10), 1331-1350 (2023-10-07)
Mesial temporal lobe epilepsy (MTLE) is the most common focal epilepsy. One-third of patients have drug-refractory seizures and are left with suboptimal therapeutic options such as brain tissue-destructive surgery. Here, we report the development and characterization of a cell therapy
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