ABC517

Anti-PGAM5 Antibody

from rabbit, purified by affinity chromatography

• 동의어(들): Serine/threonine-protein phosphatase PGAM5, mitochondrial, Bcl-XL-binding protein v68, Phosphoglycerate mutase family member 5
• UNSPSC 코드: 12352203
• eCl@ss: 32160702
• NACRES: NA.41

속성

• 생물학적 소스: rabbit
• Quality Level: 100
• 항체 형태: affinity isolated antibody
• 항체 생산 유형: primary antibodies
• 클론: polyclonal
• 정제법: affinity chromatography
• 종 반응성: human
• 종 반응성(상동성에 의해 예측): primate (based on 100% sequence homology), chimpanzee (based on 100% sequence homology), rodent (based on 100% sequence homology), monkey (based on 100% sequence homology), hamster (based on 100% sequence homology)
• 기술: western blot: suitable
• NCBI 수납 번호: NP_001164014
• UniProt 수납 번호: Q96HS1
• 배송 상태: wet ice
• 타겟 번역 후 변형: unmodified
• 유전자 정보: human ... PGAM5(192111)

설명

일반 설명

PGAM5 is a mitochondrial specific phosphatase specific for serine/threonine residues. PGAM5 principally dephosphorylates and activates MAP3K5 kinase a critical player in many cancers. PGAM5 also acts as a central mediator for programmed necrosis or necroptosis, induced by TNF, ROS or calcium. In the mitochondria, PGAM5 may also function as a regulator of mitochondrial dynamics and reconstruction. Also PGAM5 functions in the cellular stress response and regulates the removal of damaged mitochondria via mitophagy. PGAM5 itself is regulated at the protein level by the mitochondrial specific rhomboid protease PARL, which cleaves the N-terminal of PGAM5 in response to mitochondrial depolarization.

특이성

This antibody detects the -L(long) isoform and -S(short) isoform of PGAM5.

면역원

Epitope: Near N-terminal

KLH-conjugated linear peptide corresponding to human PGAM5 near the N-terminal.

애플리케이션

Research Category
Apoptosis & Cancer

Research Sub Category
Apoptosis - Additional

This Anti-PGAM5 Antibody is validated for use in Western Blotting for the detection of PGAM5.

품질

Evaluated by Western Blotting in HT-29 cell lysate.

Western Blotting Analysis: 1.0 µg/mL of this antibody detected PGAM5 in 10 µg of HT-29 cell lysate.

표적 설명

~32/34 kDa observed.

물리적 형태

Affinity purified

Purified rabbit polyclonal in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.

저장 및 안정성

Stable for 1 year at 2-8°C from date of receipt.

기타 정보

Concentration: Please refer to lot specific datasheet.

면책조항

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

안전성 정보

• Storage Class Code: 12 - Non Combustible Liquids
• WGK: WGK 1
• Flash Point (°F): Not applicable
• Flash Point (°C): Not applicable