ABC342

Anti-KPNA2 Antibody

from rabbit, purified by affinity chromatography

• 동의어(들): Karyopherin alpha nucleoprotein interactor 2, Importin alpha2, IPOA1, RAG cohort protein 1, QIP2, Karyopherin subunit alpha-2, SRP1-alpha
• UNSPSC 코드: 12352203
• eCl@ss: 32160702
• NACRES: NA.41

속성

• 생물학적 소스: rabbit
• 항체 형태: affinity isolated antibody
• 항체 생산 유형: primary antibodies
• 클론: polyclonal
• 정제법: affinity chromatography
• 종 반응성: rat, human
• 기술: immunohistochemistry: suitable; western blot: suitable
• UniProt 수납 번호: P52292
• 배송 상태: wet ice
• 타겟 번역 후 변형: unmodified
• 유전자 정보: human ... KPNA2(3838)

설명

일반 설명

Karyopherin alpha nucleoprotein interactor 2 (KPNA2), also known as Importin alpha-2, RAG cohort protein 1 (RCH1), SRP1-alpha QIP2 (SRP1), is the alpha subunit 2 of karyopherin which functions as a cargo carrier that transports various complexes from cytoplasm into nucleus and forms a complex with importin subunit beta-1 and. KPNA2 is expressed ubiquitously and contains one IBB/importin beta domain, ten Armadillo repeats and three intervening nuclear localization sequences (NLSs). Recent studies have shown that KPNA2 plays an important role in tumorigenesis and tumor progression. KPNA2 is a heterodimer with KPNB1. It has been implied to interact with HIV-1 Vpr, PLAG1, ANP32E, ARL4A, CTNNBL1, NBN and APEX1 (via N-terminus). KPNA2 is also a component of a complex containing CSE1L, RAN and KPNA2 and interacts directly with CSE1L.

면역원

KLH-conjugated linear peptide corresponding to human KPNA2.

애플리케이션

Detect Importin using this rabbit polyclonal antibody, Anti-KPNA2 Antibody validated for use in western blotting & IHC.

Immunohistochemistry Analysis: 5 µg/mL from a representative lot detected KPNA2 in human heart tissue.

Research Category
Apoptosis & Cancer

Research Sub Category
Apoptosis - Additional

품질

Evaluated by Western Blotting in rat heart tissue lysate.

Western Blotting Analysis: 2 µg/mL of this antibody detected KPNA2 in 15 µg of rat heart tissue lysate.

표적 설명

~55 kDa observed. Uncharacterized bands may appear in some lysate(s).

물리적 형태

Antigen Affinity Purified

Purified rabbit polyclonal in buffer containing PBS with up to 0.1% sodium azide.

저장 및 안정성

Stable for 1 year at 2-8°C from date of receipt.

분석 메모

Control
Rat heart tissue lysate

기타 정보

Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.

면책조항

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

안전성 정보

• Storage Class Code: 10 - Combustible liquids
• WGK: WGK 2
• Flash Point (°F): Not applicable
• Flash Point (°C): Not applicable