추천 제품
제품명
Anti-Vinculin Antibody, from rabbit, purified by affinity chromatography
생물학적 소스
rabbit
항체 형태
affinity isolated antibody
항체 생산 유형
primary antibodies
클론
polyclonal
정제법
affinity chromatography
종 반응성
rat, human, mouse
기술
western blot: suitable
NCBI 수납 번호
UniProt 수납 번호
배송 상태
wet ice
타겟 번역 후 변형
unmodified
유전자 정보
human ... VCL(7414)
일반 설명
Cell spreading and movement occur though the process of binding of cell surface integrin receptors to extracellular matrix adhesion molecules. In mammalian cells, vinculin is a membrane-cytoskeletal protein in focal adhesion plaques that is involved in linkage of integrin adhesion molecules to the actin cytoskeleton. More specifically, vinculin binds to talin at its N-terminus, which, in turn, binds to beta integrins. At its C-terminus, vinculin binds to actin, phospholipids, and paxillin-forming homodimers. The binding complex of vinculin to talin and actin serves to anchor actin filaments to the membrane, (Ezzell, 1997).
Vinculin′s ability to interact with integrins at the focal adhesion appears to be critical for control of cytoskeletal mechanics, cell spreading, and lamellipodia formation. Thus, vinculin appears to play a key role in shape control based on its ability to modulate focal adhesion structure and function.
Vinculin′s ability to interact with integrins at the focal adhesion appears to be critical for control of cytoskeletal mechanics, cell spreading, and lamellipodia formation. Thus, vinculin appears to play a key role in shape control based on its ability to modulate focal adhesion structure and function.
특이성
Predicted to cross react with monkey, pig, cow, and horse based on sequence homology.
The antibody recognizes an internal domain of human vinculin.
면역원
Epitope: Internal Domain
KLH-conjugated synthetic peptide corresponding to an internal domain of human Vinculin.
애플리케이션
Detect Vinculin using this Anti-Vinculin Antibody validated for use in WB.
Research Category
Cell Structure
Cell Structure
Research Sub Category
Cytoskeletal Signaling
Cytoskeleton
Cytoskeletal Signaling
Cytoskeleton
품질
Evaluated on a representative lot by Western blot on HepG2 cell lysate using Anti-Vinculin.
표적 설명
~ 124 kDa
물리적 형태
Antigen Affinity Purified
Purified in buffer containing 0.1 M Tris-Glycine, pH 7.4, 150 mM NaCl with 0.05% sodium azide.
저장 및 안정성
Stable for 1 year at 2-8°C from date of receipt.
분석 메모
Control
HepG2 cell lysate.
HepG2 cell lysate.
기타 정보
Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.
면책조항
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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Storage Class Code
12 - Non Combustible Liquids
WGK
WGK 1
Flash Point (°F)
Not applicable
Flash Point (°C)
Not applicable
시험 성적서(COA)
제품의 로트/배치 번호를 입력하여 시험 성적서(COA)을 검색하십시오. 로트 및 배치 번호는 제품 라벨에 있는 ‘로트’ 또는 ‘배치’라는 용어 뒤에서 찾을 수 있습니다.
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