AB2263
Anti-MEF2D Antibody
from rabbit, purified by affinity chromatography
동의어(들):
myocyte enhancer factor 2D, MADS box transcription enhancer factor 2, polypeptide D (myocyte enhancer factor 2D), MEF2D/DAZAP1 fusion, myocyte-specific enhancer factor 2D, myocyte enhancer factor 2D/deleted in azoospermia associated protein 1 fusion prot
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모든 사진(2)
About This Item
UNSPSC 코드:
12352203
eCl@ss:
32160702
NACRES:
NA.41
추천 제품
생물학적 소스
rabbit
항체 형태
affinity isolated antibody
항체 생산 유형
primary antibodies
클론
polyclonal
정제법
affinity chromatography
종 반응성
rhesus macaque, rat, human, mouse, pig, horse
종 반응성(상동성에 의해 예측)
equine (based on 100% sequence homology), porcine (based on 100% sequence homology), rhesus monkey (based on 100% sequence homology), canine (based on 100% sequence homology)
기술
immunohistochemistry: suitable (paraffin)
western blot: suitable
NCBI 수납 번호
UniProt 수납 번호
배송 상태
wet ice
타겟 번역 후 변형
unmodified
유전자 정보
human ... MEF2D(4209)
일반 설명
Myocyte-specific enhancer factor 2D is a transcriptional activator belonging to the MEF2 family. MEF2D has two domains of interest; a MADS-box domain, and a Mef2-type DNA-binding domain specifically binding to 5′-YTA[AT]4TAR-3′, the MEF2 element, which is observed in several gene types such as growth factor, muscle-specific, and stress-induced genes. MEF2D regulates various cellular processes including those within cardiac and skeletal muscle development, neuronal survival and differentiation, as well as cell growth, apoptosis and survival. MEF2D, along with ERK5, plays a vital role in neuronal survival by regulating the anti-apoptotic molecule, bcl-w. There are 6 known isoforms of MEF2D resulting from alternative splicing.
면역원
KLH-conjugated linear peptide corresponding to human MEF2D.
애플리케이션
Anti-MEF2D Antibody is an antibody against MEF2D for use in WB, IH(P).
Immunohistochemistry Analysis: 1:300 dilution from a previous lot detected MEF2D in normal human breast skin and inflammatory skin tissue.
Research Category
Neuroscience
Neuroscience
Research Sub Category
Neurodegenerative Diseases
Neurodegenerative Diseases
품질
Evaluated by Western Blot in L6 cell lysate.
Western Blot Analysis: 0.5 µg/mL of this antibody detected MEF2D on 10 µg of L6 cell lysate.
Western Blot Analysis: 0.5 µg/mL of this antibody detected MEF2D on 10 µg of L6 cell lysate.
표적 설명
Observed at ~ 54 kDa
물리적 형태
Affinity purified
Purified rabbit polyclonal in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
저장 및 안정성
Stable for 1 year at 2-8°C from date of receipt.
분석 메모
Control
L6 cell lysate
L6 cell lysate
기타 정보
Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.
면책조항
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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Storage Class Code
12 - Non Combustible Liquids
WGK
WGK 1
Flash Point (°F)
Not applicable
Flash Point (°C)
Not applicable
시험 성적서(COA)
제품의 로트/배치 번호를 입력하여 시험 성적서(COA)을 검색하십시오. 로트 및 배치 번호는 제품 라벨에 있는 ‘로트’ 또는 ‘배치’라는 용어 뒤에서 찾을 수 있습니다.
Kristina A Sharlo et al.
International journal of molecular sciences, 24(1) (2023-01-09)
Muscle unloading leads to signaling alterations that cause muscle atrophy and weakness. The cellular energy sensor AMPK can regulate myofiber-type shift, calcium-dependent signaling and ubiquitin-proteasome system markers. We hypothesized that the prevention of p-AMPK downregulation during the first week of
Kristina A Sharlo et al.
International journal of molecular sciences, 22(3) (2021-02-13)
It was observed that gravitational unloading during space missions and simulated microgravity in ground-based studies leads to both transformation of slow-twitch muscle fibers into fast-twitch fibers and to the elimination of support afferentation, leading to the "switching-off" of postural muscle
P J Nicholls et al.
eNeuro, 9(5) (2023-01-14)
The protease caspase-3 is a key mediator of apoptotic programmed cell death. But weak or transient caspase activity can contribute to neuronal differentiation, axonal pathfinding, and synaptic long-term depression. Despite the importance of sublethal, or nonapoptotic, caspase activity in neurodevelopment
Inna I Paramonova et al.
Pharmaceuticals (Basel, Switzerland), 14(11) (2021-11-28)
It is well known that reduced contractile activity of the main postural soleus muscle during long-term bedrest, immobilization, hindlimb unloading, and space flight leads to increased expression of fast isoforms and decreased expression of the slow isoform of myosin heavy
Fernando Josa-Prado et al.
PloS one, 14(2), e0212857-e0212857 (2019-02-23)
Protein SUMOylation regulates multiple processes involved in the differentiation and maturation of cells and tissues during development. Despite this, relatively little is known about the spatial and temporal regulation of proteins that mediate SUMOylation and deSUMOylation in the CNS. Here
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