AB16942
Anti-DR5 Antibody, CT
Chemicon®, from rabbit
동의어(들):
Anti-CD262, Anti-DR5, Anti-KILLER, Anti-KILLER/DR5, Anti-TRAIL-R2, Anti-TRAILR2, Anti-TRICK2, Anti-TRICK2A, Anti-TRICK2B, Anti-TRICKB, Anti-ZTNFR9
로그인조직 및 계약 가격 보기
모든 사진(3)
크기 선택
보기 변경
100 μG
₩742,473
About This Item
UNSPSC 코드:
12352203
eCl@ss:
32160702
NACRES:
NA.41
추천 제품
생물학적 소스
rabbit
Quality Level
항체 형태
affinity purified immunoglobulin
항체 생산 유형
primary antibodies
클론
polyclonal
분자량
calculated mol wt-47.88 kDa
observed mol wt ~55 kDa
종 반응성
human
제조업체/상표
Chemicon®
기술
western blot: suitable
NCBI 수납 번호
UniProt 수납 번호
배송 상태
wet ice
타겟 번역 후 변형
unmodified
유전자 정보
human ... TNFRSF10B(8795)
특이성
Apoptosis is induced by certain cytokines including TNF and Fas ligand in the TNF family through their death domain containing receptors. TRAIL/Apo2L is a new member of the TNF family. DR4 was recently identified as the receptor for TRAIL. A novel death domain containing receptor for TRAIL was more recently identified and designated DR5, Apo2, TRAIL-R2, TRICK2 or KILLER by several groups independently (Pan et al. 1997; Sheridan et al. 1997; Walczak et al. 1997; MacFarlane et al. 1997; Screaton et al. 1997; Wu et al. 1997; Chaudhary et al. 1997). Like DR4, DR5 transcript is widely expressed in normal tissues and in many types of tumor cells. DR5 binds to TRAIL and mediates TRAIL induced cell death. Overexpression of DR5 induces apoptosis and activates NF-kB.
면역원
Epitope: C-terminus
Polyclonal antibody raised against a peptide corresponding to amino acids 388-407 of human DR5 precursor (Pan et al. 1997; Sheridan et al. 1997).
애플리케이션
Anti-DR5 Antibody, C-terminus detects level of DR5 & has been published & validated for use in WB.
Research Category
Apoptosis & Cancer
Apoptosis & Cancer
Research Sub Category
Apoptosis - Additional
Apoptosis - Additional
Western blot: 1:250 to 1:500
Whole cell lysate from HeLa or K562 cells can be used as a positive control .
Optimal working dilutions must be determined by end user.
Whole cell lysate from HeLa or K562 cells can be used as a positive control .
Optimal working dilutions must be determined by end user.
물리적 형태
Affinity purified immunoglobulin. Liquid in PBS containing 0.02% sodium azide.
Format: Purified
저장 및 안정성
Maintain refrigerated at 2-8°C in undiluted aliquots for up to 12 months.
기타 정보
Click here for more information on observed vs. calculated molecular weight.
Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.
Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.
법적 정보
CHEMICON is a registered trademark of Merck KGaA, Darmstadt, Germany
면책조항
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
적합한 제품을 찾을 수 없으신가요?
당사의 제품 선택기 도구.을(를) 시도해 보세요.
Storage Class Code
10 - Combustible liquids
WGK
WGK 2
Flash Point (°F)
Not applicable
Flash Point (°C)
Not applicable
시험 성적서(COA)
제품의 로트/배치 번호를 입력하여 시험 성적서(COA)을 검색하십시오. 로트 및 배치 번호는 제품 라벨에 있는 ‘로트’ 또는 ‘배치’라는 용어 뒤에서 찾을 수 있습니다.
Mini Jeong et al.
International journal of molecular sciences, 24(2) (2023-01-22)
Rheumatoid arthritis (RA) is an inflammatory disease marked by a massive proliferation of synovial cells in the joints. In this study, we investigated the pro-apoptotic effects of docosahexaenoic acid (DHA) in human fibroblast-like synovial cells from RA patients (RA-FLS). An
Florent Dufour et al.
Oncotarget, 8(6), 9974-9985 (2017-01-01)
TRAIL induces selective tumor cell death through TRAIL-R1 and TRAIL-R2. Despite the fact that these receptors share high structural homologies, induction of apoptosis upon ER stress, cell autonomous motility and invasion have solely been described to occur through TRAIL-R2. Using
Marie-Laure Plissonnier et al.
Oncotarget, 8(64), 107744-107762 (2018-01-04)
Known activators of the Peroxisome Proliferator-Activated Receptor γ (PPARγ), thiazolidinediones (TZD) induce apoptosis in a variety of cancer cells through dependent and/or independent mechanisms of the receptor. We tested a panel of TZD (Rosiglitazone, Pioglitazone, Ciglitazone) to shed light on
Andrei Alexandru Constantinescu et al.
Methods in molecular biology (Clifton, N.J.), 1557, 19-31 (2017-01-13)
Analysis of CD95/Fas complexes by immunoprecipitation has long relied on the monoclonal antibody APO1 or tagged recombinant Fas ligand. Immunoprecipitation is an elegant and efficient procedure to investigate endogenous protein interactions or complexes. Provided that the targeted complex is soluble
Mohammed I Y Elmallah et al.
Oncology reports, 37(6), 3635-3642 (2017-04-26)
Tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) is a promising anticancer agent, as it can kill tumor cells selectively. In our search of bioactive natural products to overcome TRAIL-resistance, we isolated 47 actinomycete strains from different sediments and seawater samples collected
활성 필터
자사의 과학자팀은 생명 과학, 재료 과학, 화학 합성, 크로마토그래피, 분석 및 기타 많은 영역을 포함한 모든 과학 분야에 경험이 있습니다..
고객지원팀으로 연락바랍니다.
