추천 제품
제품명
Anti-Amyloid Precursor Protein Antibody, a.a. 44-63, serum, Chemicon®
생물학적 소스
goat
Quality Level
항체 형태
serum
항체 생산 유형
primary antibodies
클론
polyclonal
종 반응성
human
제조업체/상표
Chemicon®
기술
ELISA: suitable
immunofluorescence: suitable
immunohistochemistry (formalin-fixed, paraffin-embedded sections): suitable
western blot: suitable
NCBI 수납 번호
UniProt 수납 번호
배송 상태
dry ice
타겟 번역 후 변형
unmodified
유전자 정보
human ... APP(351)
특이성
Recognizes amyloid precursor protein (APP). In Alzheimer′s disease, this protein is broken down and releases the 12 amino acid b-amyloid protein that is found in senile plaques and vessels.
The amyloid precursor protein is the subject of intensive investigations to determine how this protein is broken down abnormally in Alzheimer′s disease to give rise to the b-amyloid protein which is present in senile plaques and vessels. This antiserum has been shown to be immunoreactive to the immunizing peptide by ELISA. The antiserum will immunolabel dystrophic neurites in senile plaques in both formalin-fixed paraffin sections and paraformaldehyde fixed frozen sections from Alzheimer′s brain.
This antiserum should be a valuable tool for scientist and neuropathologists who study the role of amyloid in Alzheimer′s′s disease.
The amyloid precursor protein is the subject of intensive investigations to determine how this protein is broken down abnormally in Alzheimer′s disease to give rise to the b-amyloid protein which is present in senile plaques and vessels. This antiserum has been shown to be immunoreactive to the immunizing peptide by ELISA. The antiserum will immunolabel dystrophic neurites in senile plaques in both formalin-fixed paraffin sections and paraformaldehyde fixed frozen sections from Alzheimer′s brain.
This antiserum should be a valuable tool for scientist and neuropathologists who study the role of amyloid in Alzheimer′s′s disease.
면역원
Epitope: a.a. 44-63
Peptide to the N-terminal region (amino acids 44-63) of the APP protein.
애플리케이션
Anti-Amyloid Precursor Protein Antibody, a.a. 44-63 is an antibody against Amyloid Precursor Protein for use in ELISA, IF, WB, IH, IH(P).
Immunoblotting: 1:1,000
Immunofluorescence
Immunohistochemistry
Formalin fixed paraffin embedded tissue:1:50-1:100
4% paraformaldehyde fixed frozen sections: 1:2,500-1:5,000
ELISA: 1:1,500 against immunogen peptide
Optimal working dilutions must be determined by end user.
Immunofluorescence
Immunohistochemistry
Formalin fixed paraffin embedded tissue:1:50-1:100
4% paraformaldehyde fixed frozen sections: 1:2,500-1:5,000
ELISA: 1:1,500 against immunogen peptide
Optimal working dilutions must be determined by end user.
Research Category
Neuroscience
Neuroscience
Research Sub Category
Neurodegenerative Diseases
Neurodegenerative Diseases
물리적 형태
Goat antiserum. Liquid with 0.1% Sodium Azide
저장 및 안정성
Store at -20ºC in undiluted aliquots for up to 12 months. Avoid repeated freeze/thaw cycles.
법적 정보
CHEMICON is a registered trademark of Merck KGaA, Darmstadt, Germany
면책조항
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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Storage Class Code
12 - Non Combustible Liquids
WGK
WGK 1
Flash Point (°F)
Not applicable
Flash Point (°C)
Not applicable
시험 성적서(COA)
제품의 로트/배치 번호를 입력하여 시험 성적서(COA)을 검색하십시오. 로트 및 배치 번호는 제품 라벨에 있는 ‘로트’ 또는 ‘배치’라는 용어 뒤에서 찾을 수 있습니다.
Grant T Corbett et al.
Proceedings of the National Academy of Sciences of the United States of America, 112(27), 8445-8450 (2015-06-17)
Amyloid precursor protein (APP) derivative β-amyloid (Aβ) plays an important role in the pathogenesis of Alzheimer's disease (AD). Sequential proteolysis of APP by β-secretase and γ-secretase generates Aβ. Conversely, the α-secretase "a disintegrin and metalloproteinase" 10 (ADAM10) cleaves APP within
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