AB15134

Anti-Neurotensin Receptor 2 Antibody

from rabbit, purified by affinity chromatography

• 동의어(들): Levocabastine-sensitive neurotensin receptor, NTR2 receptor, neurotensin receptor 2, neurotensin receptor, type 2
• UNSPSC 코드: 12352203
• eCl@ss: 32160702
• NACRES: NA.41

속성

• 생물학적 소스: rabbit
• 항체 형태: affinity isolated antibody
• 항체 생산 유형: primary antibodies
• 클론: polyclonal
• 정제법: affinity chromatography
• 종 반응성: human, mouse, rat
• 기술: immunohistochemistry: suitable; western blot: suitable
• NCBI 수납 번호: NP_036476
• UniProt 수납 번호: O95665
• 배송 상태: wet ice
• 유전자 정보: human ... NTSR2(23620)

설명

일반 설명

Neurotensin Receptor 2 (NTR2) is a member of the G-protein coupled receptor family. Neurotensin is a 13 amino acid peptide that induces hypothermia and mediates analgesia when administered centrally, and also mediates the behavioral effects of antipsychotic drugs in rodents (Kinkead and Nemeroff, 2004). In addition, several intestinal functions, such as contractility and inflammation, are mediated by neurotensin (Castagliuolo et al., 1999). The actions of neurotensin are mediated by two GPCRs, NTR1 (or NTS1) and NTR2 (or NTS2). NTR2 recognizes a histamine H1 receptor antagonist that had been shown to compete with neurotensin for low-affinity binding sites in the brain.

특이성

This antibody recognizes Neurotensin Receptor 2.

면역원

Epitope: Extracellular Domain

KLH-conjugated linear peptide from the extracellular domain of human Neurotensin Receptor 2.

애플리케이션

Detect Neurotensin Receptor 2 using this Anti-Neurotensin Receptor 2 Antibody validated for use in WB, IH.

Research Category
Neuroscience

Metabolism

Research Sub Category
Neurotransmitters & Receptors

Hormones & Receptors

Western Blot Analysis: 1 µg/ml of this antibody detected Neurotensin Receptor 2 in 10 µg of mouse brain lysate.

Western Blot Analysis: 1 µg/ml of this antibody detected Neurotensin Receptor 2 in 10 µg of rat brain lysate.

품질

Evaluated by Western Blot in human cortex lysate.

Western Blot Analysis: 1 µg/ml of this antibody detected Neurotensin Receptor 2 in 10 µg of human cortex lysate.

표적 설명

45.413 kDa is the calculated molecular weight. In Western Blot, immunoreactive bands which might reflect multimeric species of Neurotensin Receptor 2, are detected at approximately 60-65 kDa, 75 kDa, and 80-85 kDa Sarret, P., et al. (2003). J Comp Neurol. 461(4):520-538.

결합

Replaces: AB9521

물리적 형태

Affinity purified

Purified rabbit polyclonal in buffer containing 0.1 M Tris-Glycine (pH 7.4, 150 mM NaCl) with 0.05% sodium azide.

저장 및 안정성

Stable for 1 year at 2-8°C from date of receipt.

분석 메모

Control
Human cortex lysate

기타 정보

Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.

면책조항

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

안전성 정보

• Storage Class Code: 12 - Non Combustible Liquids
• WGK: WGK 1
• Flash Point (°F): Not applicable
• Flash Point (°C): Not applicable