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Merck
모든 사진(1)

주요 문서

869003-M

Sigma-Aldrich

Luteinizing Hormone, Human Pituitary, Iodination Grade

동의어(들):

Luteinizing Hormone, Human Pituitary, Iodination Grade, hLH

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About This Item

CAS Number:
MDL number:
UNSPSC 코드:
12352202
NACRES:
NA.77
가격 및 재고 정보를 현재 이용할 수 없음

생물학적 소스

human

Quality Level

설명

Merck USA index - 14, 5613

분석

≥95% (weight)

양식

solid

제조업체/상표

Calbiochem®

저장 조건

OK to freeze

불순물

≤0.05% hCG
≤0.5% hFSH, hTSH

색상

white

solubility

water: 1 mg/mL

저장 온도

−20°C

일반 설명

Native, human luteinizing hormone from pituitary gland. Heterodimeric glycoprotein hormone secreted by the anterior pituitary gland that is required for ovulation, spermatogenesis, and the biosynthesis of sex steroids. Regulates biosynthesis and/or secretion of sex steroids. In the female, LH stimulates synthesis of progesterone in the ovaries, release of estrogen from Graafian follicles, induction of ovulation, and formation of the corpus luteum. In the male, LH stimulates testosterone secretion by the testes. Biological specificity has been attributed to the β-chain.

생화학적/생리학적 작용

≥ 5,000 IU/mg

경고

Toxicity: Carcinogenic / Teratogenic (D)

기타 정보

Ramanujam, L.N., et al. 1999. Clin. Endocrinol.51, 243.

법적 정보

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point (°F)

Not applicable

Flash Point (°C)

Not applicable


시험 성적서(COA)

제품의 로트/배치 번호를 입력하여 시험 성적서(COA)을 검색하십시오. 로트 및 배치 번호는 제품 라벨에 있는 ‘로트’ 또는 ‘배치’라는 용어 뒤에서 찾을 수 있습니다.

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질문

1–2 / 2 질문  
  1. Could you please provide instructions on how to reconstitute product number 869003, specifically Luteinizing Hormone, Human Pituitary, Iodination Grade?

    1 답변
    1. The solubility of gonadorelin (acetate) in ethanol is roughly 0.25 mg/ml and about 30 mg/ml in DMSO and DMF.

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  2. Hello, Can this iodination grade hLH be used in rat LH radioimmunoassay or do you carry any iodination grade rLH?

    1 답변
    1. The suitability of this product in rat studies has not been determined. It has been shown that iodination may lower the potency of LH and a lower affinity to hormonal receptors. It may be helpful to view a similar product L6420. Again, this product has not been tested for suitability in rat.


      Below are some references that may be helpful in determining if these products would be suitable for the specified application.

      1. Effect of Iodination on the Biological Activity and Metabolism of Human Luteinizing Hormone
      https://academic.oup.com/jcem/article-abstract/28/5/613/2715632

      2. Iodination of Luteinizing Hormone-Releasing Hormone
      https://pubs.acs.org/doi/pdf/10.1021/bi00553a006

      3. Species specificity in the response of an in vitro amphibian (Xenopus laevis) ovulation assay to mammalian luteinizing hormones
      https://www.sciencedirect.com/science/article/pii/0016648076900393

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