8.52175

Fmoc-Ala-Ser(psiMe,Mepro)-OH

Novabiochem^®

• 동의어(들): Fmoc-Ala-Ser(psiMe,Mepro)-OH
• 실험식(Hill 표기법): C₂₄H₂₆N₂O₆
• CAS Number: 252554-78-2
• Molecular Weight: 438.47
• MDL number: MFCD11226795
• UNSPSC 코드: 12352209
• NACRES: NA.22

속성

• Quality Level: 200
• 제품 라인: Novabiochem^®
• 분석: ≥97% (TLC); ≥97.0% (HPLC)
• 양식: powder
• 반응 적합성: reaction type: Fmoc solid-phase peptide synthesis
• 제조업체/상표: Novabiochem^®
• 응용 분야: peptide synthesis
• 작용기: hydroxyl
• 저장 온도: 2-8°C
• SMILES string: N4([C@@H](COC4(C)C)C(=O)O)C(=O)[C@@H](NC(=O)OCC1c2c(cccc2)c3c1cccc3)C
• InChI: 1S/C24H26N2O6/c1-14(21(27)26-20(22(28)29)13-32-24(26,2)3)25-23(30)31-12-19-17-10-6-4-8-15(17)16-9-5-7-11-18(16)19/h4-11,14,19-20H,12-13H2,1-3H3,(H,25,30)(H,28,29)/t14-,20-/m0/s1
• InChI key: QMRGOZHWQFEGGB-XOBRGWDASA-N

설명

일반 설명

This pseudoproline dipeptide is undoubtedly the most effective and simplest to use tool for overcoming aggregation and enhancing peptide quality in Fmoc SPPS for peptide containing the Ala-Ser dipeptide motif. It consists of a dipeptide in which the serine residue has been reversibly protected as a structure-breaking proline-like TFA-labile oxazolidine. The reason the pseudoproline residue is introduced as a dipeptide is because it avoids the need to acylate the hindered oxazolidine nitrogen. This has the added advantage of extending the peptide chain by two residues in one step. The serine residue is regenerated during the normal TFA-mediated cleavage reaction.

Associated Protocols and Technical Articles
Cleavage and Deprotection Protocols for Fmoc SPPS
Overcoming Aggregation in Fmoc SPPS

결합

Replaces: 05-20-1000

분석 메모

Color (visual): white to slight yellow to beige
Appearance of substance (visual): powder
Identity (IR): passes test
Optical rotation α 25/D (c=1 in methanol): -44.0 - -37.0 °
Purity (TLC(157A)): ≥ 97 %
Purity (TLC(CMA2)): ≥ 97 %
Assay (HPLC, area%): ≥ 97.0 % (a/a)
Single impurities (HPLC, area%): ≤ 1.00 % (a/a)
Acetate (IC): ≤ 0.1 %
Ethyl acetate (HS-GC): ≤ 2.0 %

To see the solvent systems used for TLC of Novabiochem^® products please click here.

법적 정보

Novabiochem is a registered trademark of Merck KGaA, Darmstadt, Germany

안전성 정보

• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 2
• Flash Point (°F): Not applicable
• Flash Point (°C): Not applicable