8.52007

Fmoc-Cys(tBu)-OH

Novabiochem^®

• 동의어(들): Fmoc-Cys(tBu)-OH, N-α-Fmoc-S-t.-butyl-L-cysteine
• 실험식(Hill 표기법): C₂₂H₂₅NO₄S
• CAS Number: 67436-13-9
• Molecular Weight: 399.50
• MDL number: MFCD00037130
• UNSPSC 코드: 12352209
• NACRES: NA.22

속성

• Quality Level: 200
• 제품 라인: Novabiochem^®
• 분석: ≥97.0% (acidimetric); ≥98% (TLC); ≥98.0% (HPLC)
• 형태: powder
• 반응 적합성: reaction type: Fmoc solid-phase peptide synthesis
• 제조업체/상표: Novabiochem^®
• mp: 133-136 °C
• 응용 분야: peptide synthesis
• 작용기: thiol
• 저장 온도: 2-30°C
• InChI: 1S/C22H25NO4S/c1-22(2,3)28-13-19(20(24)25)23-21(26)27-12-18-16-10-6-4-8-14(16)15-9-5-7-11-17(15)18/h4-11,18-19H,12-13H2,1-3H3,(H,23,26)(H,24,25)
• InChI key: IXAYZHCPEYTWHW-UHFFFAOYSA-N

설명

일반 설명

The side-chain tBu group is stable to TFA and iodine oxidation. Treatment with MeSiCl₃/PhSOPh removes t-Bu and cyclizes in one step without scrambling existing disulphide bonds. Removed with Hg(II) to give cysteinyl peptides.

Associated Protocols and Technical Articles
Cleavage and Deprotection Protocols for Fmoc SPPS
Fmoc SPPS of Cysteine-Containing Peptides

Literature references

^[1] S. N. McCurdy (1989) Pept. Res., 2, 147.

결합

Replaces: 04-12-1016

분석 메모

Colour (visual): white to slight yellow to beige
Appearance of substance (visual): powder
Identity (IR): passes test
Enantiomeric purity: ≥ 99.5 % (a/a)
Purity (TLC(011A)): ≥ 98 %
Purity (TLC(0811)): ≥ 98 %
Assay (HPLC, area%): ≥ 98.0 % (a/a)
Solubility (1 mmole in 2 ml DMF): clearly soluble
Assay (acidimetric): ≥ 97.0 %
Water (K. F.): ≤ 1.00 %

To see the solvent systems used for TLC of Novabiochem^® products please click here.

법적 정보

Novabiochem is a registered trademark of Merck KGaA, Darmstadt, Germany

안전성 정보

• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point (°F): Not applicable
• Flash Point (°C): Not applicable