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Merck
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주요 문서

8.00907

Sigma-Aldrich

N-(3-Dimethylaminopropyl)-N′-ethylcarbodiimide hydrochloride

for peptide synthesis

동의어(들):

N-(3-Dimethylaminopropyl)-N′-ethylcarbodiimide hydrochloride

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크기 선택

1 G
₩42,021
5 G
₩154,280
25 G
₩437,262

₩42,021


예상 입고일2025년 4월 16일세부사항


벌크 견적 요청

크기 선택

보기 변경
1 G
₩42,021
5 G
₩154,280
25 G
₩437,262

About This Item

실험식(Hill 표기법):
C8H17N3 · xHCl
CAS Number:
Molecular Weight:
155.24 (free base basis)
MDL number:
UNSPSC 코드:
12352107
EC 인덱스 번호:
247-361-2
NACRES:
NA.22

₩42,021


예상 입고일2025년 4월 16일세부사항


벌크 견적 요청

제품명

N-(3-Dimethylaminopropyl)-N′-ethylcarbodiimide hydrochloride, for synthesis

Quality Level

양식

solid

반응 적합성

reaction type: Coupling Reactions

mp

110-115 °C

응용 분야

peptide synthesis

저장 온도

−20°C (−15°C to −25°C)

SMILES string

Cl.N(CCCN(CC)C#N)(C)C

InChI

1S/C8H17N3.ClH/c1-4-11(8-9)7-5-6-10(2)3;/h4-7H2,1-3H3;1H

InChI key

FDXPUDRRFDHONO-UHFFFAOYSA-N

일반 설명

N-(3-Dimethylaminopropyl)-N-ethylcarbodiimide hydrochloride, also known as EDAC HCl or WSC, is a water-soluble condensing reagent. EDAC HCl is generally used to couple carboxylic acids with amines to form amides. The by-product urea is water-soluble and can be removed from immiscible reaction milieux by extraction with water. It is principally utilized in solution-phase peptide synthesis and as a zero-length crosslinker for protein modification.

애플리케이션

N-(3-Dimethylaminopropyl)-N′-ethylcarbodiimide hydrochloride (EDC hydrochloride) can be used as:
  • A water-soluble carbodiimide to facilitate peptide coupling reactions in alcohols.[1]
  • A coupling agent along with HOBt to synthesize poly(glutamic acid) (PGA) polypeptides for the creation of non-fouling polypeptides that could be useful in a variety of biomedical applications.[2]
  • A coupling reagent for the efficient synthesis of teriflunomide at the industrial scale.[3]

픽토그램

Skull and crossbonesHealth hazardEnvironment

신호어

Danger

유해 및 위험 성명서

Hazard Classifications

Acute Tox. 3 Dermal - Acute Tox. 4 Oral - Aquatic Acute 1 - Aquatic Chronic 1 - Skin Irrit. 2 - Skin Sens. 1 - STOT RE 2 Oral

Storage Class Code

6.1C - Combustible, acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

WGK

WGK 3

Flash Point (°F)

Not applicable

Flash Point (°C)

Not applicable


시험 성적서(COA)

제품의 로트/배치 번호를 입력하여 시험 성적서(COA)을 검색하십시오. 로트 및 배치 번호는 제품 라벨에 있는 ‘로트’ 또는 ‘배치’라는 용어 뒤에서 찾을 수 있습니다.

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질문

1–3 / 3 질문  
  1. How can I determine the shelf life / expiration / retest date of this product?

    1 답변
    1. If this product has an expiration or retest date, it will be shown on the Certificate of Analysis (COA, CofA). If there is no retest or expiration date listed on the product's COA, we do not have suitable stability data to determine a shelf life. For these products, the only date on the COA will be the release date; a retest, expiration, or use-by-date will not be displayed.
      For all products, we recommend handling per defined conditions as printed in our product literature and website product descriptions. We recommend that products should be routinely inspected by customers to ensure they perform as expected.
      For products without retest or expiration dates, our standard warranty of 1 year from the date of shipment is applicable.
      For more information, please refer to the Product Dating Information document: https://www.sigmaaldrich.com/deepweb/assets/sigmaaldrich/marketing/global/documents/449/386/product-dating-information-mk.pdf

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  2. How is shipping temperature determined? And how is it related to the product storage temperature?

    1 답변
    1. Products may be shipped at a different temperature than the recommended long-term storage temperature. If the product quality is sensitive to short-term exposure to conditions other than the recommended long-term storage, it will be shipped on wet or dry-ice. If the product quality is NOT affected by short-term exposure to conditions other than the recommended long-term storage, it will be shipped at ambient temperature. As shipping routes are configured for minimum transit times, shipping at ambient temperature helps control shipping costs for our customers. For more information, please refer to the Storage and Transport Conditions document: https://www.sigmaaldrich.com/deepweb/assets/sigmaaldrich/marketing/global/documents/316/622/storage-transport-conditions-mk.pdf

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  3. The packaging instructions recommend storing the item under an inert gas, but the safety data sheet does not specify this requirement. Would it suffice to store it in a refrigerator at -20°C instead?

    1 답변
    1. The recommended long term storage of this item is -15°C to -25°C. Clearing the headspace of the vial with argon before resealing is recommended. The stability of the product when stored otherwise cannot be guaranteed.

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