688100

YC-1

A nitric oxide-independent, superoxide-sensitive activator of soluble guanylyl cyclase.

• 동의어(들): YC-1, 3-(5ʹ-Hydroxymethyl-2ʹ-furyl)-1-benzylindazole
• 실험식(Hill 표기법): C₁₉H₁₆N₂O₂
• CAS Number: 170632-47-0
• Molecular Weight: 304.34
• MDL number: MFCD06407798
• UNSPSC 코드: 12352200

속성

• Quality Level: 100
• 분석: ≥98% (HPLC)
• 양식: solid
• 제조업체/상표: Calbiochem^®
• 저장 조건: OK to freeze; desiccated; protect from light
• 색상: off-white to pale yellow
• solubility: DMSO: 10 mg/mL; methanol: 5 mg/mL
• 배송 상태: ambient
• 저장 온도: −20°C
• InChI: 1S/C19H16N2O2/c22-13-15-10-11-18(23-15)19-16-8-4-5-9-17(16)21(20-19)12-14-6-2-1-3-7-14/h1-11,22H,12-13H2
• InChI key: OQQVFCKUDYMWGV-UHFFFAOYSA-N

설명

일반 설명

A nitric oxide-independent, superoxide-sensitive activator of soluble guanylyl cyclase. Inhibits platelet adhesion to collagen and acts as an antithrombotic agent.

A nitric oxide-independent, superoxide-sensitive activator of soluble guanylyl cyclase. Inhibits platelet adhesion to collagen and acts as an antithrombotic agent. Reported to reduce HIF-1α levels and xenograft growth.

생화학적/생리학적 작용

Cell permeable: no

Primary Target
Activator of soluble guanylyl cyclase

Product does not compete with ATP.

Reversible: no

경고

Toxicity: Standard Handling (A)

재구성

Following reconstitution, aliquot and freeze (-20°C). DMSO stock solutions are stable for up to 3 months at -20°C.

기타 정보

Yeo, E.J., et al. 2003. J. Natl Cancer Inst.95, 516.
Mulsch, A., et al. 1997. Br. J. Pharmacol. 120, 681.
Teng, C.M., et al. 1997. Eur. J. Pharmacol. 320, 161.
Wu, C.C., et al. 1997. Biochem. Biophys. Res. Commun. 231, 412.
Wu, C.C., et al. 1995. Br. J. Pharmacol. 116, 1973.

법적 정보

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

안전성 정보

• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point (°F): Not applicable
• Flash Point (°C): Not applicable