658425

AG 17

Anti-proliferative agent that acts as a selective inhibitor of the platelet-derived growth factor receptor tyrosine kinase (IC₅₀ = 500 nM).

• 동의어(들): AG 17, NSC 242557, 3,5-di- t-Butyl-4-hydroxy-benzylidenemalononitrile, α-Cyano-(3,5-di- t-butyl-4-hydroxy)cinnamonitrile, Tyrphostin A9, RG 50872
• 실험식(Hill 표기법): C₁₈H₂₂N₂O
• CAS Number: 10537-47-0
• Molecular Weight: 282.38
• MDL number: MFCD00209853
• UNSPSC 코드: 12352200
• NACRES: NA.77

속성

• Quality Level: 100
• 설명: RTECS - OO3737000
• 분석: ≥99% (TLC)
• 양식: solid
• 제조업체/상표: Calbiochem^®
• 저장 조건: OK to freeze; protect from light
• 색상: pale yellow
• solubility: DMSO: 10 mg/mL; ethanol: 5 mg/mL
• 배송 상태: ambient
• 저장 온도: −20°C
• SMILES string: N#CC(=Cc1cc(c(c(c1)C(C)(C)C)O)C(C)(C)C)C#N
• InChI: 1S/C18H22N2O/c1-17(2,3)14-8-12(7-13(10-19)11-20)9-15(16(14)21)18(4,5)6/h7-9,21H,1-6H3
• InChI key: MZOPWQKISXCCTP-UHFFFAOYSA-N

설명

일반 설명

A selective, cell-permeable, reversible, and substrate competitive inhibitor of the platelet-derived growth factor receptor tyrosine kinase (IC₅₀ = 500 nM). Anti-proliferative agent. Uncoupler of oxidative phosphorylation. Induces apoptosis in vitro and cell growth arrest in NHL cell lines.

Anti-proliferative agent that acts as a selective inhibitor of the platelet-derived growth factor receptor tyrosine kinase (IC₅₀ = 500 nM). A potent, cell-permeable, reversible, and substrate competitive inhibitor of TNF-induced tyrosine phosphorylation of PYK2. Uncouples oxidative phosphorylation and induces apoptosis and cell growth arrest in NHL cell lines. Inhibits Cdk2 activity in lymphoma cell lines.

생화학적/생리학적 작용

Cell permeable: yes

Primary Target
Platelet-derived growth factor receptor tyrosine kinase

Product competes with ATP.

Reversible: yes

Target IC₅₀: 500 nM against platelet-derived growth factor receptor tyrosine kinase

경고

Toxicity: Toxic (F)

재구성

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 1 month at -20°C.

기타 정보

Due to the nature of the Hazardous Materials in this shipment, additional shipping charges may be applied to your order. Certain sizes may be exempt from the additional hazardous materials shipping charges. Please contact your local sales office for more information regarding these charges.

Fuortes, M., et al. 1999. J. Clin. Invest.104, 327.
Palumbo, G.A., et al. 1997. Cancer Res. 57, 2434.
Burger, A.M., et al. 1995. Cancer Res.55, 2794.
Palumbo, G.A., et al. 1994. Blood84, 296a.
Bilder, G.E., et al. 1991. Am. J. Physiol. 260, C721.
Levitzki, A., and Gilon, S. 1991. Trends Pharmacol. Sci. 12, 171.
Terada, H. 1981. Biochim. Biophys. Acta639, 225

법적 정보

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

안전성 정보

• 픽토그램: GHS06
• 신호어: Danger
• 유해 및 위험 성명서: H301 + H311
• 예방조치 성명서: P264 - P270 - P280 - P301 + P310 - P302 + P352 + P312 - P361 + P364
• Hazard Classifications: Acute Tox. 3 Dermal - Acute Tox. 3 Oral
• Storage Class Code: 6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
• WGK: WGK 3
• Flash Point (°F): Not applicable
• Flash Point (°C): Not applicable