분석
≥98% (TLC)
Quality Level
양식
solid
색상
yellow
solubility
ethanol: 10 mg/mL
DMSO: soluble
acetic acid: soluble
일반 설명
An inactive compound that can be used as a negative control for inhibition of EGFR (IC50 >1250 μM for EGFR kinase). Has been shown to inhibit IL-2 stimulated Tyk-2 phosphorylation in ConA-activated T cells.
생화학적/생리학적 작용
negative control for inhibition of EGFR
Target IC<SUB>50</SUB>:>1250 μM for EGFR kinase
Target IC<SUB>50</SUB>:>1250 μM for EGFR kinase
재구성
Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 1 month at -20°C.
Storage Class Code
10-13 - German Storage Class 10 to 13
시험 성적서(COA)
제품의 로트/배치 번호를 입력하여 시험 성적서(COA)을 검색하십시오. 로트 및 배치 번호는 제품 라벨에 있는 ‘로트’ 또는 ‘배치’라는 용어 뒤에서 찾을 수 있습니다.
H Ruetten et al.
British journal of pharmacology, 122(1), 59-70 (1997-09-23)
1 Here we compared the effects of various inhibitors of the activity of protein tyrosine kinase on (i) the expression of the activity of the inducible isoform of nitric oxide (NO) synthase (iNOS) caused by endotoxin (lipopolysaccharide, LPS) in cultured
J J Bright et al.
Journal of immunology (Baltimore, Md. : 1950), 162(10), 6255-6262 (1999-05-07)
IL-12 is a macrophage-derived cytokine that induces proliferation, cytokine production, and cytotoxic activity of T and NK cells. Signaling through its receptor, IL-12 induces these cellular responses by tyrosine phosphorylation and activation of Janus kinase-2 (Jak-2), Tyk-2, Stat3, and Stat4.
A Gazit et al.
Journal of medicinal chemistry, 32(10), 2344-2352 (1989-10-01)
A novel class of low molecular weight protein tyrosine kinase inhibitors is described. These compounds constitute a systematic series of molecules with a progressive increase in affinity toward the substrate site of the EGF receptor kinase domain. These competitive inhibitors
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