648450-M

TrkA Inhibitor

The TrkA Inhibitor, also referenced under CAS 388626-12-8, controls the biological activity of TrkA. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications.

• 동의어(들): TrkA Inhibitor
• 실험식(Hill 표기법): C₁₅H₁₃N₃O₃S
• CAS Number: 388626-12-8
• Molecular Weight: 315.35
• UNSPSC 코드: 12352200

속성

• 분석: ≥97% (sum of two isomers, HPLC)
• 양식: solid
• 제조업체/상표: Calbiochem^®
• 저장 조건: OK to freeze; protect from light
• 색상: yellow
• solubility: DMSO: 200 mg/mL
• 저장 온도: 2-8°C

설명

일반 설명

A potent, cell-permeable, reversible, and highly selective inhibitor of TrkA (IC₅₀ = 63 nM), presumably by targeting the ATP binding pocket. Shown to exhibit ≥150-fold selectivity over Cdk1 and cRaf1.

An oxindole compound that acts as a cell-permeable, reversible, potent, and highly selective inhibitor of TrkA (IC₅₀ = 63 nM), presumably by targeting the kinase’s ATP binding pocket. Shown to exhibit ≥150-fold selectivity over Cdk1 and cRaf1.

생화학적/생리학적 작용

Primary Target
TrkA

Target IC₅₀: 63 nM against TrkA

경고

Toxicity: Standard Handling (A)

재구성

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

기타 정보

Wood, E.R., et al. 2004. Bioorg. Med. Chem. Lett.14, 953.

법적 정보

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

안전성 정보

• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 1
• Flash Point (°F): Not applicable
• Flash Point (°C): Not applicable