616467
ZDON
≥98% (HPLC), powder, transglutaminase 2 inhibitor, Calbiochem®
동의어(들):
Transglutaminase 2 Inhibitor, ZDON, Z-DON, 6-diazo-5-oxo-norleucine tetrapeptide, TG2 Inhibitor
로그인조직 및 계약 가격 보기
크기 선택
5 MG
₩406,203
₩406,203
예상 입고일2025년 5월 07일세부사항
모든 사진(1)
크기 선택
보기 변경
5 MG
₩406,203
About This Item
실험식(Hill 표기법):
C31H45N7O9
Molecular Weight:
659.73
UNSPSC 코드:
12352200
NACRES:
NA.54
₩406,203
예상 입고일2025년 5월 07일세부사항
추천 제품
제품명
Transglutaminase 2 Inhibitor, ZDON, A cell-permeable, peptide-based, irreversible inhibitor of transglutaminase 2 (TG2; IC₅₀ = 150 nM for recombinant TG2). Reacts with the active site cysteine of TG2.
Quality Level
분석
≥98% (HPLC)
양식
powder
제조업체/상표
Calbiochem®
저장 조건
OK to freeze
색상
off-white
solubility
DMSO: 50 mg/mL
배송 상태
ambient
저장 온도
−20°C
일반 설명
A cell-permeable, peptide-based (Z- QVPL) irreversible inhibitor of transglutaminase 2 (TG2) (IC50 = 150 nM for recombinant TG2) that acts by reacting with the active site cysteine of TG2. Exhibits far less potency against TG1 and TG3. Shown to significantly increase PGC-1a and cytochrome c mRNA levels in Q7 and Q111 cells (~50 mM). Also shown to enhance cytochrome c promoter activity by 250% in Q111 cells. Exhibits protective effect in cells exposed to 3-nitropropionic acid and NMDA, however, it does not directly affect mitochondrial bioenergetics.
경고
Toxicity: Standard Handling (A)
재구성
Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
기타 정보
McConoughey, S. J., et al. 2010. EMBO Mol. Medicine.2, 349.
법적 정보
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
Storage Class Code
11 - Combustible Solids
WGK
WGK 1
Flash Point (°F)
Not applicable
Flash Point (°C)
Not applicable
시험 성적서(COA)
제품의 로트/배치 번호를 입력하여 시험 성적서(COA)을 검색하십시오. 로트 및 배치 번호는 제품 라벨에 있는 ‘로트’ 또는 ‘배치’라는 용어 뒤에서 찾을 수 있습니다.
Min-Su Han et al.
Scientific reports, 10(1), 13228-13228 (2020-08-09)
Transglutaminase 2 (TG2), also known as tissue transglutaminase, is a calcium-dependent enzyme that has a variety of intracellular and extracellular substrates. TG2 not only increases in osteoarthritis (OA) tissue but also affects the progression of OA. However, it is still
Manuel Lisetto et al.
International journal of molecular sciences, 24(15) (2023-08-12)
Transglutaminase 2 (TG2) is a multifunctional protein widely distributed in various tissues and involved in many physiological and pathological processes. However, its actual role in biological processes is often controversial as TG2 shows different effects in these processes depending on
Anurag Rathore et al.
Scientific reports, 10(1), 5350-5350 (2020-03-27)
The major barrier to a HIV-1 cure is the persistence of latent genomes despite treatment with antiretrovirals. To investigate host factors which promote HIV-1 latency, we conducted a genome-wide functional knockout screen using CRISPR-Cas9 in a HIV-1 latency cell line
활성 필터
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