610225

Tigecycline

A broad-spectrum glyclcycline class of antimicrobial agent that is active against both Gram positive and Gram negative bacteria.

• 동의어(들): Tigecycline, 9- t-Butylglycylamido-minocycline, 9-t-Butylglycylamido-minocycline
• 실험식(Hill 표기법): C₂₉H₃₉N₅O₈
• CAS Number: 220620-09-7
• Molecular Weight: 585.65
• MDL number: MFCD00935753
• UNSPSC 코드: 12352200

속성

• Quality Level: 100
• 분석: ≥99% (HPLC)
• 형태: powder
• 제조업체/상표: Calbiochem^®
• 저장 조건: OK to freeze; protect from light
• 색상: orange
• solubility: DMSO: soluble
• 배송 상태: ambient
• 저장 온도: 2-8°C
• SMILES string: O=C(C1=C(O)[C@@](C(C(C(N)=O)=C(O)[C@H]2N(C)C)=O)(O)[C@@]2([H])C[C@]1([H])C3)C4=C3C(N(C)C)=CC(NC(CNC(C)(C)C)=O)=C4O
• InChI: 1S/C29H39N5O8/c1-28(2,3)31-11-17(35)32-15-10-16(33(4)5)13-8-12-9-14-21(34(6)7)24(38)20(27(30)41)26(40)29(14,42)25(39)18(12)23(37)19(13)22(15)36/h10,12,14,21,31,36-37,41-42H,8-9,11,30H2,1-7H3,(H,32,35)/b27-20-/t12-,14-,21-,29-/m0/s1
• InChI key: ZXGBRIBPJBHLMO-SBMFAFPZSA-N

설명

일반 설명

A broad-spectrum glyclcycline class of antimicrobial agent that is active against both Gram positive and Gram negative bacteria. Exhibits toxicity for human AML cells at all stages of development in both in vitro and in vivo models. Selectively kills leukemic stem and progenitor cells (LD₅₀ ~10 µM) and reduces the repopulating ability of the primary AML cells while sparing normal hematopoietic cells. Its action on growth and viability of eukaryotic cells is shown to be due to its inhibitory effects on mitochondrial protein translation and respiratory complex activity.

포장

Packaged under inert gas

경고

Toxicity: Irritant (B)

재구성

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

기타 정보

Skrtic, M., et al. 2011. Cancer Cell20, 674.
Olson, M.W., et al. 2006. Antimicrob. Agents Chemother.50, 2156.
Stein, G.E., and Craig, W.A., 2006. Clin. Infect Dis.43, 518.
Livermore, D.M., 2005. J. Antimicrob. Chemother.56, 611.

법적 정보

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

안전성 정보

• 픽토그램: GHS08,GHS05,GHS07,GHS09
• 신호어: Danger
• 유해 및 위험 성명서: H317,H318,H360FD,H410
• 예방조치 성명서: P202 - P273 - P280 - P302 + P352 - P305 + P351 + P338 - P308 + P313
• Hazard Classifications: Aquatic Acute 1 - Aquatic Chronic 2 - Eye Dam. 1 - Repr. 1B - Skin Sens. 1
• Storage Class Code: 6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
• WGK: WGK 3
• Flash Point (°F): Not applicable
• Flash Point (°C): Not applicable