573108-M

STAT5 Inhibitor

The STAT5 Inhibitor, also referenced under CAS 285986-31-4, controls the biological activity of STAT5.

• 동의어(들): STAT5 Inhibitor, Nʹ-((4-Oxo-4H-chromen-3-yl)methylene)nicotinohydrazide
• 실험식(Hill 표기법): C₁₆H₁₁N₃O₃
• CAS Number: 285986-31-4
• Molecular Weight: 293.28
• MDL number: MFCD00124694
• UNSPSC 코드: 12352200

속성

• Quality Level: 100
• 분석: ≥97% (HPLC)
• 양식: solid
• 제조업체/상표: Calbiochem^®
• 저장 조건: OK to freeze; protect from light
• 색상: white
• solubility: DMSO: 25 mg/mL
• 저장 온도: 2-8°C
• SMILES string: N(\N=C\c2[c](c3c([o]c2)cccc3)=O)C(=O)c1cnccc1
• InChI key: DAVIKTBRCQWOGT-GIJQJNRQSA-N

설명

일반 설명

A cell-permeable nonpeptidic nicotinoyl hydrazone compound that selectively targets the SH2 domain of STAT5 (IC₅₀ = 47 µM against STAT5b SH2 domain EPO peptide binding activity), while exhibiting much less effect towards the SH2 domain of STAT1, STAT3, or Lck (IC₅₀ >500 µM). Shown to block STAT5/STAT5 DNA binding activity in K562 nuclear extract and inhibit IFN-α-stimulated STAT5, but not STAT1 or STAT3, tyrosine phosphorylation in Daudi cells.

경고

Toxicity: Standard Handling (A)

기타 정보

Muller, J., et al. 2008. ChemBioChem9, 723.

법적 정보

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

안전성 정보

• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point (°F): Not applicable
• Flash Point (°C): Not applicable