572636

SU6656

InSolution, ≥95%, inhibitor of Src-family protein tyrosine kinases

• 동의어(들): InSolution SU6656
• 실험식(Hill 표기법): C₁₉H₂₁N₃O₃S
• Molecular Weight: 371.45
• UNSPSC 코드: 12352200
• NACRES: NA.77

속성

• Quality Level: 100
• 분석: ≥95% (HPLC)
• 형태: liquid
• 제조업체/상표: Calbiochem^®
• 저장 조건: OK to freeze; desiccated (hygroscopic); protect from light
• 배송 상태: wet ice
• 저장 온도: 2-8°C

설명

일반 설명

A potent inhibitor of Src-family protein tyrosine kinases. Inhibits Src (IC₅₀ = 280 nM) as well as closely related kinases Fyn (IC₅₀ = 170 nM), Yes (IC₅₀ = 20 nM) and Lyn (IC₅₀ = 130 nM). The inhibition is competitive with respect to ATP. Has only a trivial effect on Lck (IC₅₀ = 6.88 µM). Does not affect the activity of PDGF-β receptor kinase (IC₅₀ >10 µM) and IGF-1 receptor kinase (IC₅₀ gt;20 µM).

생화학적/생리학적 작용

Cell permeable: yes

Product competes with ATP.

Reversible: yes

Target IC₅₀: 280 nM inhibiting Src

포장

Packaged under inert gas

경고

Toxicity: Irritant (B)

물리적 형태

A 10 mM (500 µg/135 µl) solution of SU6656 (Cat. No. 572635) in DMSO.

법적 정보

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

안전성 정보

• Storage Class Code: 10 - Combustible liquids
• WGK: WGK 2
• Flash Point (°F): 188.6 °F - closed cup - (Dimethylsulfoxide)
• Flash Point (°C): 87 °C - closed cup - (Dimethylsulfoxide)