553031

RAGE Antagonist Peptide, RAP

The RAGE Antagonist Peptide, RAP controls the biological activity of RAGE.

• 동의어(들): RAGE Antagonist Peptide, RAP, ELKVLMEKEL
• 실험식(Hill 표기법): C₅₇H₁₀₁N₁₃O₁₇S
• Molecular Weight: 1272.55
• UNSPSC 코드: 12352111
• NACRES: NA.77

속성

• Quality Level: 200
• 분석: ≥95% (HPLC)
• 형태: powder
• 효능: 2 μM IC₅₀
• 제조업체/상표: Calbiochem^®
• 저장 조건: OK to freeze; protect from light
• 색상: white
• solubility: water: 5 mg/mL
• 배송 상태: dry ice
• 저장 온도: −20°C

설명

일반 설명

An S100P-derived peptide based competitive antagonist for receptor for advanced glycation end product (RAGE). Shown to disrupt the interaction between RAGE and its ligands, such as S100P, S100A4 and HMGB-1 in binding assays and in multiple cancer cell lines (~2 µM). Also, blocks RAGE-dependent NF-kB activation in MPanc96, MOH and HPAF II tumor cell lines. Systemic administration of RAP also diminishes NF-kB signaling in vivo and significantly reduces glioma tumor growth in murine models.

생화학적/생리학적 작용

Primary Target
RAGE

Reversible: yes

포장

Packaged under inert gas

경고

Toxicity: Standard Handling (A)

서열

Ac-ELKVLMEKEL-NH2

물리적 형태

Supplied as a trifluoroacetate salt.

재구성

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

기타 정보

Arumugam, T., et al. 2012. Clin Cancer Res.18, 4356.

법적 정보

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

안전성 정보

• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 1
• Flash Point (°F): Not applicable
• Flash Point (°C): Not applicable