5.34356

PRMT5 Inhibitor, CMP5

• 동의어(들): PRMT5 Inhibitor, CMP5, 1-(9-Ethyl-9H-carbazol-3-yl)-N-(2-pyridinylmethyl)methanamine, 2HCl, 1-(9-Ethyl-9H-carbazol-3-yl)-N-(pyridin-2-ylmethyl)methanamine, 2HCl
• 실험식(Hill 표기법): C₂₁H₂₁N₃ · 2HCl
• Molecular Weight: 388.33
• UNSPSC 코드: 12352200
• NACRES: NA.77

속성

• 분석: ≥98% (HPLC)
• Quality Level: 100
• 형태: solid
• 제조업체/상표: Calbiochem^®
• 저장 조건: OK to freeze; desiccated (hygroscopic); protect from light
• 색상: yellow
• solubility: DMSO: 25 mg/mL; water: 50 mg/mL
• 저장 온도: 2-8°C

설명

일반 설명

A cell-permeable carbazole based compound that selectively inhibits PRMT5 and not PRMT1, PRMT4 & PRMT7 activity. Shown to occupy hPRMT5 catalytic site and block symmetrically dimethylated S2Me-H4R3 & S2Me-H3R8 with no effect on the asymmetric methylation of H4R3 in lymphoblastoid cell lines at 40 µM. Prevents Epstein-Barr virus (EBV)-driven B cell immortalization and restores miR-96 transcriptional activity. Dose-dependently induces lymphoma cell death over normal resting B lymphocytes.

A cell-permeable carbazole based compound that selectively inhibits PRMT5 and not PRMT1, PRMT4 & PRMT7 activity. Shown to occupy hPRMT5 catalytic site and block symmetrically dimethylated S2Me-H4R3 & S2Me-H3R8 with no effect on the asymmetric methylation of H4R3 in lymphoblastoid cell lines at 40 µM. Prevents Epstein-Barr virus (EBV)-driven B cell immortalization and restores miR-96 transcriptional activity. Dose-dependently induces lymphoma cell death over normal resting B lymphocytes.

Please note that the molecular weight for this compound is batch-specific due to variable water content. Please refer to the vial label or the certificate of analysis for the batch-specific molecular weight. The molecular weight provided represents the baseline molecular weight without water.

생화학적/생리학적 작용

Cell permeable: yes

Primary Target
PRMT5

Reversible: yes

포장

Packaged under inert gas

경고

Toxicity: Standard Handling (A)

물리적 형태

Supplied as HCl salt.

재구성

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

기타 정보

Alinari, L., et al. 2015. Blood.125, 2530.

법적 정보

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

안전성 정보

• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point (°F): Not applicable
• Flash Point (°C): Not applicable