5.08505

A-803467

• 동의어(들): A-803467, Sodium Channel Type 1.8 (Nav1.8) blocker, A-803467, A 803467, A803467
• 실험식(Hill 표기법): C₁₉H₁₆ClNO₄
• CAS Number: 944261-79-4
• Molecular Weight: 357.79
• MDL number: MFCD10574689
• UNSPSC 코드: 12352200
• NACRES: NA.77

속성

• 분석: ≥98% (HPLC)
• Quality Level: 100
• 형태: solid
• 효능: 8 nM IC₅₀
• 제조업체/상표: Calbiochem^®
• 저장 조건: OK to freeze; protect from light
• 색상: white
• solubility: DMSO: 100 mM; ethanol: 25 mM
• 저장 온도: 2-8°C
• InChI: 1S/C19H16ClNO4/c1-23-15-9-14(10-16(11-15)24-2)21-19(22)18-8-7-17(25-18)12-3-5-13(20)6-4-12/h3-11H,1-2H3,(H,21,22)
• InChI key: VHKBTPQDHDSBSP-UHFFFAOYSA-N

설명

일반 설명

A voltage gated sodium channel type 1.8 (Na_v1.8) pore blocker. Potently blocks tetrodotoxin-resistant currents (IC₅₀) = 140 nM) and the generation of spontaneous and electrically evoked action potentials in vitro in rat dorsal root ganglion neurons. In recombinant cell lines, A-803467 potently blocked human Na_v1.8 (IC₅₀ = 8 nM) and was >100-fold selective vs. human Na_v1.2, Na_v1.3, Na_v1.5, and Na_v1.7 (IC₅₀ values ≥ 1 µM).

생화학적/생리학적 작용

Primary Target
Na_v1.8

경고

Toxicity: Standard Handling (A)

기타 정보

Jarvis, M. F. et al. 2007. Proc. Natl. Acad. Sci. USA104, 8520.

법적 정보

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

안전성 정보

• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point (°F): Not applicable
• Flash Point (°C): Not applicable